Starčič Erjavec Marjanca, Žgur-Bertok Darja
Department of Biology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
Department of Biology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
FEMS Microbiol Lett. 2015 Mar;362(5). doi: 10.1093/femsle/fnu061. Epub 2015 Feb 5.
Previous investigations have indicated that the reservoir of extraintestinal pathogenic Escherichia coli (ExPEC) strains is the intestinal microbiota. Nevertheless, studies focused on the prevalence of potential ExPEC strains among the bowel microbiota in healthy human individuals practically do not exist and a strong bias towards pathogenic strains among the E. coli data set is obvious. To assess the prevalence of potential ExPEC strains among E. coli from the intestinal microbiota of healthy humans, we performed a search for data on the prevalence of virulence-associated genes and pathogenicity islands among fecal E. coli found in published studies, including studies comparing isolates from patients suffering from extraintestinal E. coli infections with E. coli from feces of healthy humans. An extensive literature search, including more than 500 published papers, revealed 24 papers with data on prevalences of ≥ 5 virulence-associated genes among 21 E. coli collections including ≥ 20 fecal/rectal strains obtained from healthy individuals and 4 papers with prevalences of pathogenicity islands among E. coli collections from healthy humans. The gathered data are presented in this minireview and clearly show that potential ExPEC strains are present among fecal isolates with a prevalence of around ≥ 10%.
先前的调查表明，肠外致病性大肠杆菌（ExPEC）菌株的储存库是肠道微生物群。然而，实际上不存在针对健康个体肠道微生物群中潜在ExPEC菌株流行情况的研究，并且在大肠杆菌数据集中对致病菌株存在明显的偏差。为了评估健康人肠道微生物群中大肠杆菌中潜在ExPEC菌株的流行情况，我们搜索了已发表研究中粪便大肠杆菌中毒力相关基因和致病岛流行情况的数据，包括比较肠外大肠杆菌感染患者的分离株与健康人粪便中大肠杆菌的研究。广泛的文献检索，包括500多篇已发表的论文，揭示了24篇关于21个大肠杆菌集合中≥5个毒力相关基因流行情况的数据，这些集合包括≥20株从健康个体获得的粪便/直肠菌株，以及4篇关于健康人大肠杆菌集合中致病岛流行情况的论文。本综述呈现了收集到的数据，清楚地表明粪便分离株中存在潜在的ExPEC菌株，其流行率约≥10%。
