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免疫重建炎症综合征暴露麻风结节性红斑：一例罕见病例报告。

Immune reconstitution inflammatory syndrome unmasking erythema nodosum leprosum: a rare case report.

作者信息

Arakkal Geeta Kiran, Damarla Sudha Vani, Chanda Geetha Madhuri

机构信息

Department of Dermatology, Venereology and Leprosy, Gandhi Medical College, Secunderabad, Andhra Pradesh, India.

出版信息

Indian J Dermatol. 2015 Jan-Feb;60(1):106. doi: 10.4103/0019-5154.147883.

DOI:10.4103/0019-5154.147883
PMID:25657440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4318046/
Abstract

Immune reconstitution inflammatory syndrome (IRIS) occurs as an acute symptomatic expression of a latent infection during the recovery of immune system in response to antiretroviral therapy in HIV patients. IRIS triggers both opportunistic and non-opportunistic infections. We report a case of IRIS in a patient with HIV, presenting as erythema nodosum leprosum (ENL), which led to unmasking of lepromatous leprosy following anti-retroviral therapy (ART).

摘要

免疫重建炎症综合征（IRIS）是HIV患者在接受抗逆转录病毒治疗后免疫系统恢复过程中，潜在感染的一种急性症状表现。IRIS可引发机会性感染和非机会性感染。我们报告一例HIV患者发生IRIS的病例，表现为结节性红斑型麻风（ENL），该病例在抗逆转录病毒治疗（ART）后导致瘤型麻风暴露。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/d7a652ed6abf/IJD-60-106f-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/6fec88adf975/IJD-60-106f-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/0d315662ab6a/IJD-60-106f-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/f3cdd948d6fb/IJD-60-106f-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/c4bfe005f8f9/IJD-60-106f-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/d7a652ed6abf/IJD-60-106f-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/6fec88adf975/IJD-60-106f-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/0d315662ab6a/IJD-60-106f-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/f3cdd948d6fb/IJD-60-106f-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/c4bfe005f8f9/IJD-60-106f-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/443a/4318046/d7a652ed6abf/IJD-60-106f-g005.jpg

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BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.05.2009.1904. Epub 2009 Dec 1.
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Leprosy occurring as immune reconstitution syndrome.麻风病表现为免疫重建综合征。
Trans R Soc Trop Med Hyg. 2008 Oct;102(10):966-8. doi: 10.1016/j.trstmh.2008.06.003. Epub 2008 Jul 18.
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Towards understanding the pathology of erythema nodosum leprosum.
迈向对麻风结节性红斑病理学的理解。
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Immune reconstitution inflammatory syndrome in HIV-infected patients receiving antiretroviral therapy : pathogenesis, clinical manifestations and management.接受抗逆转录病毒治疗的HIV感染患者的免疫重建炎症综合征：发病机制、临床表现及管理
Drugs. 2008;68(2):191-208. doi: 10.2165/00003495-200868020-00004.
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Interactions between HIV infection and leprosy: a paradox.HIV感染与麻风病之间的相互作用：一个悖论。
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