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追踪肺祖细胞的潜能。

Tracing the potential of lung progenitors.

作者信息

Mahoney John E, Kim Carla F

机构信息

Stem Cell Program at Boston Children's Hospital and the Department of Genetics at Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Nat Biotechnol. 2015 Feb;33(2):152-4. doi: 10.1038/nbt.3139.

DOI:10.1038/nbt.3139
PMID:25658282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7485088/
Abstract

Transplanted lung progenitor cells give rise to specialized epithelial cells, raising new possibilities for treating lung disease.

摘要

移植的肺祖细胞可分化为特化的上皮细胞,为治疗肺部疾病带来了新的可能性。

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Tracing the potential of lung progenitors.追踪肺祖细胞的潜能。
Nat Biotechnol. 2015 Feb;33(2):152-4. doi: 10.1038/nbt.3139.
2
Stem cells: Emergency back-up for lung repair.干细胞:肺修复的紧急后备军。
Nature. 2015 Jan 29;517(7536):556-7. doi: 10.1038/517556a.
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Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.谱系阴性祖细胞在严重损伤后动员起来以再生肺上皮。
Nature. 2015 Jan 29;517(7536):621-5. doi: 10.1038/nature14112. Epub 2014 Dec 24.
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p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.p63(阳性)Krt5(阳性)的远端气道干细胞对肺再生至关重要。
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Regeneration of the adult thymus is preceded by the expansion of K5+K8+ epithelial cell progenitors and by increased expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma.成年胸腺的再生之前,胸腺基质中K5+K8+上皮细胞祖细胞会发生扩增,且Trp63、cMyc和Tcf3转录因子的表达会增加。
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Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment.用博来霉素对小鼠气道进行预处理可提高原位肺癌细胞植入的效率。
J Vis Exp. 2018 Jun 28(136):56650. doi: 10.3791/56650.
2
Rare SOX2 Airway Progenitor Cells Generate KRT5 Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.罕见的SOX2气道祖细胞可产生KRT5细胞,这些细胞在流感病毒感染后可重新填充受损的肺泡实质。
Stem Cell Reports. 2016 Nov 8;7(5):817-825. doi: 10.1016/j.stemcr.2016.09.010. Epub 2016 Oct 20.

本文引用的文献

1
Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza.流感实验小鼠模型中的上皮内T细胞细胞毒性、诱导支气管相关淋巴组织及肺细胞增殖
Viral Immunol. 2014 Dec;27(10):484-96. doi: 10.1089/vim.2014.0077.
2
Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.呼吸系统的修复与再生:复杂性、可塑性及肺干细胞功能机制
Cell Stem Cell. 2014 Aug 7;15(2):123-38. doi: 10.1016/j.stem.2014.07.012.
3
Type 2 alveolar cells are stem cells in adult lung.
2 型肺泡细胞是成人肺部的干细胞。
J Clin Invest. 2013 Jul;123(7):3025-36. doi: 10.1172/JCI68782. Epub 2013 Jun 10.
4
Stem cells and regenerative medicine in lung biology and diseases.肺部生物学和疾病中的干细胞和再生医学。
Mol Ther. 2012 Jun;20(6):1116-30. doi: 10.1038/mt.2012.37. Epub 2012 Mar 6.
5
Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection.远端气道干细胞在体外产生肺泡,并在 H1N1 流感感染后肺再生期间产生肺泡。
Cell. 2011 Oct 28;147(3):525-38. doi: 10.1016/j.cell.2011.10.001.
6
Distinct stem cells contribute to mammary gland development and maintenance.不同的干细胞对乳腺的发育和维持起着重要作用。
Nature. 2011 Oct 9;479(7372):189-93. doi: 10.1038/nature10573.
7
Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice.整合素 α6β4 鉴定出一种具有再生潜力的成年小鼠远端肺上皮细胞群体。
J Clin Invest. 2011 Jul;121(7):2855-62. doi: 10.1172/JCI57673. Epub 2011 Jun 23.
8
The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium.Scgb1a1⁺克拉拉细胞在肺气道而非肺泡上皮的长期维持和修复中的作用。
Cell Stem Cell. 2009 Jun 5;4(6):525-34. doi: 10.1016/j.stem.2009.04.002.