*Institut Curie, Centre de Recherche, F-75248 Paris, France.
Essays Biochem. 2015;57:109-19. doi: 10.1042/bse0570109.
The understanding of lipid membranes and their organization has undergone significant development with better techniques and therefore more resolved experiments. Many new factors and organizing principles have been discovered, and interplay between these factors is expected to result in rich functional behaviours. The major factors regulating the lateral membrane heterogeneity, apart from the well-studied phase separation, are cytoskeleton pinning, clustering of lipids and curvature. These factors are effective means to create membrane domains that provide rich biological functionality. We review the recent advances and concepts of membrane heterogeneity organization by curvature, cytoskeleton and clustering proteins.
随着技术的进步，人们对脂质膜及其组织的理解也取得了重大进展，因此能够进行更有针对性的实验。人们发现了许多新的因素和组织原则，预计这些因素之间的相互作用将产生丰富的功能行为。除了众所周知的相分离之外，调节侧向膜异质性的主要因素还有细胞骨架固定、脂质聚集和曲率。这些因素是产生提供丰富生物学功能的膜域的有效手段。我们综述了曲率、细胞骨架和聚集蛋白调节的膜异质性组织的最新进展和概念。
