中国与隐球菌性脑膜炎相关的矛盾性免疫重建炎症综合征：一项为期 5 年的回顾性队列研究。

Paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis in China: a 5-year retrospective cohort study.

机构信息

Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, Hunan Province, China.

出版信息

Clin Microbiol Infect. 2015 Apr;21(4):379.e11-4. doi: 10.1016/j.cmi.2014.11.011. Epub 2014 Nov 20.

DOI:10.1016/j.cmi.2014.11.011

PMID:25658526

Abstract

We performed a retrospective cohort study of hospitalised cryptococcal meningitis (CM) patients at a single centre to evaluate the clinical epidemiological features of paradoxical cryptococcal-related immune reconstitution inflammatory syndrome (CM-IRIS) in a setting in China. A total of 154 AIDS patients with CM were involved, and 17.5% experienced IRIS at a median of 27 days after initiation of antiretroviral therapy (ART). Overall, 3 deaths were directly attributed to IRIS. The occurrences of CM-IRIS were independently associated with the pre-ART CD4+count, pre-C-reactive protein level, and the timing of ART initiation.

摘要

我们对一家中心医院的住院隐球菌性脑膜炎（CM）患者进行了回顾性队列研究，以评估中国环境中矛盾性隐球菌相关免疫重建炎症综合征（CM-IRIS）的临床流行病学特征。共有 154 名 AIDS 合并 CM 患者入组，其中 17.5%的患者在抗逆转录病毒治疗（ART）开始后中位 27 天发生 IRIS。总的来说，有 3 例死亡直接归因于 IRIS。CM-IRIS 的发生与 ART 前 CD4+计数、前 C 反应蛋白水平和 ART 开始时间独立相关。