2003-2013 年中国志贺菌血清型分布变迁。
Shift in serotype distribution of Shigella species in China, 2003-2013.
机构信息
Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
Shanghai Municipal Centre for Disease Control & Prevention, Shanghai, China.
出版信息
Clin Microbiol Infect. 2015 Mar;21(3):252.e5-8. doi: 10.1016/j.cmi.2014.10.019. Epub 2014 Nov 7.
We identified 2912 Shigella isolates from diarrhoeal patients in China during 2003-2013. The most common species was Shigella flexneri (55.3%), followed by Shigella sonnei (44.1%); however, S. sonnei is becoming increasingly prevalent. Among the S. flexneri isolates, serotypes 2a and X variant (-:7,8, E1037) were the two most prevalent serotypes, and serologically atypical isolates were also commonly identified. Overall, S. sonnei, S. flexneri 2a and S. flexneri X variant (-:7,8, E1037) accounted for 76.1% of all Shigella isolates, and their prevalence increased from 54.0% during 2003-2004 to 84.1% during 2011-2013. A change was observed in the serotype distribution of Shigella in China during this period, and we propose an ideal strategy to inform the development of a broadly effective Shigella vaccine candidate.
我们从 2003 年至 2013 年期间在中国腹泻患者中鉴定出 2912 株志贺氏菌。最常见的菌种为福氏志贺菌（55.3%），其次为宋内志贺菌（44.1%）；然而，宋内志贺菌的流行程度正在逐渐增加。在福氏志贺菌分离株中，血清型 2a 和 X 变种（-:7,8, E1037）是两种最常见的血清型，同时也经常鉴定出血清学非典型分离株。总体而言，宋内志贺菌、福氏志贺菌 2a 和福氏志贺菌 X 变种（-:7,8, E1037）占所有志贺氏菌分离株的 76.1%，其流行率从 2003-2004 年的 54.0%增加到 2011-2013 年的 84.1%。在此期间，中国志贺氏菌的血清型分布发生了变化，我们提出了一个理想的策略，为开发广泛有效的志贺氏菌疫苗候选物提供信息。
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