Bangtrakulnonth Aroon, Vieira Antonio R, Lo Fo Wong Danilo M A, Pornreongwong Srirat, Pulsrikarn Chaiwat, Sawanpanyalert Pathom, Hendriksen Rene S, Aarestrup Frank M
Department of Medical Sciences, WHO International Salmonella and Shigella Centre, National Institute of Health, Ministry of Public Health, Bangkok, Thailand.
Foodborne Pathog Dis. 2008 Dec;5(6):773-84. doi: 10.1089/fpd.2008.0109.
In Thailand during 1993-2006, a total of 9063 Shigella isolates from different medical centers were serotyped and trends over time and spatial clustering analyzed. Of 3583 cases with age information, 1315 (37%) cases were from children between 0 and 4 years and 684 (19%) from children between 5 and 8 years. Most infections were recorded during 1993-1994 (> 1500 per year), decreasing to < 200 in 2006. The relative species distribution also changed. During 1993-1994, Shigella flexneri accounted for 2241 (65%) of 3474 isolations. This proportion decreased to 64 (36%) of 176 infections in 2006. Most infections occurred during July and August, and fewest in December. S. flexneri clustered around Bangkok, and Shigella sonnei in southern Thailand. Most S. flexneri infections were caused by serotype 2a (1590 of 4035) followed by serotype var X (1249). For both serotypes, a pronounced decrease in the number of isolates occurred over time. A much smaller decrease was observed for serotype 3a isolates. Phase I S. sonnei was initially most common, but shifted gradually over phase I, II, to only phase II. No differences in spatial distribution were found. The three most common S. flexneri serotypes all clustered in, around, and west of Bangkok. Serotypes 2a and 3a also clustered in southern Thailand, whereas var X clustered north and northeast of Bangkok. In conclusion, looking at Shigella species, Thailand changed from being a developing country to a developed country between 1995 and 1996. In addition, major shifts in the types of S. sonnei were observed as were differences in spatial clustering of S. flexneri and S. sonnei and S. flexneri serotypes.
1993年至2006年期间，泰国对来自不同医疗中心的9063株志贺氏菌分离株进行了血清分型，并分析了其随时间的变化趋势和空间聚集情况。在3583例有年龄信息的病例中，1315例（37%）来自0至4岁的儿童，684例（19%）来自5至8岁的儿童。大多数感染记录于1993年至1994年（每年超过1500例），到2006年降至200例以下。相对物种分布也发生了变化。1993年至1994年期间，3474株分离株中，福氏志贺氏菌占2241株（65%）。这一比例在2006年降至176例感染中的64株（36%）。大多数感染发生在7月和8月，12月最少。福氏志贺氏菌聚集在曼谷周围，宋内志贺氏菌聚集在泰国南部。大多数福氏志贺氏菌感染由2a血清型引起（4035株中的1590株），其次是X变种血清型（1249株）。两种血清型的分离株数量均随时间显著减少。3a血清型分离株的减少幅度小得多。I相宋内志贺氏菌最初最为常见，但逐渐从I相转变为II相，最终仅为II相。未发现空间分布差异。三种最常见的福氏志贺氏菌血清型均聚集在曼谷及其周边和西部。2a和3a血清型也聚集在泰国南部，而X变种聚集在曼谷北部和东北部。总之，从志贺氏菌种类来看，泰国在1995年至1996年间从发展中国家转变为发达国家。此外，还观察到宋内志贺氏菌类型的主要转变，以及福氏志贺氏菌、宋内志贺氏菌及其血清型在空间聚集上的差异。
