Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Royal Cambodian Armed Forces, Phnom Penh, Cambodia.
Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0067121. doi: 10.1128/AAC.00671-21. Epub 2021 Aug 16.
Information on causative diarrheal pathogens and their associated antimicrobial susceptibility remains limited for Cambodia. This study describes antimicrobial resistance patterns for and nontyphoidal Salmonella isolates collected in Cambodia over a 5-year period. Multidrug resistance was shown in 98% of isolates, with 70%, 11%, and 29% of isolates being resistant to fluoroquinolones, azithromycin, and cephalosporin, respectively. As many as 11% of isolates were resistant to nearly all oral and parenteral drugs typically used for shigellosis, demonstrating extreme drug resistance phenotypes. Although a vast majority of nontyphoidal Salmonella isolates remained susceptible to cephalosporins (99%) and macrolides (98%), decreased susceptibility to ciprofloxacin was found in 67% of isolates, which is notably higher than previous reports. In conclusion, increasing antimicrobial resistance of and nontyphoidal Salmonella is a major concern for selecting empirical treatment of acute infectious diarrhea in Cambodia. Treatment practices should be updated and follow local antimicrobial resistance data for the identified pathogens.
柬埔寨有关致泻性病原体及其相关抗菌药物敏感性的信息仍然有限。本研究描述了在柬埔寨 5 年内收集的 和非伤寒沙门氏菌分离株的抗菌药物耐药模式。98%的 分离株表现出多药耐药性，分别有 70%、11%和 29%的分离株对氟喹诺酮类、阿奇霉素和头孢菌素耐药。多达 11%的 分离株对通常用于志贺氏菌病的几乎所有口服和注射药物均有耐药性，表现出极端的耐药表型。尽管绝大多数非伤寒沙门氏菌分离株对头孢菌素（99%）和大环内酯类（98%）仍然敏感，但发现 67%的分离株对环丙沙星的敏感性降低，这明显高于以往的报告。总之， 和非伤寒沙门氏菌的抗菌药物耐药性增加是柬埔寨选择急性感染性腹泻经验性治疗的主要关注点。治疗方案应进行更新，并根据已确定病原体的当地抗菌药物耐药数据进行调整。
