Lee Na Young, Park Hae-Young Lopilly, Park Sung-Hwan, Park Chan Kee
a College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea .
b Department of Ophthalmology , Incheon St. Mary's Hospital , Seoul , Republic of Korea .
Curr Eye Res. 2015;40(10):1001-7. doi: 10.3109/02713683.2014.971937. Epub 2015 Feb 6.
To investigate the association of nailfold capillaroscopy, heart rate variability (HRV), and clinical characteristics of glaucoma with the plasma matrix metalloproteinase-9 (MMP-9) level in normal-tension glaucoma (NTG).
We conducted a prospective, cross-sectional study on 25 patients with NTG. Subjects with systemic diseases were excluded. The patients underwent a complete ophthalmic examination and were referred to the Rheumatology Department, where nailfold capillaroscopy and HRV assessment were performed. The patients were assigned to the lowest and highest HRV groups according to the standard deviation value of the qualified normal-to-normal intervals of the HRV assessment. Blood samples from all the subjects were assayed for MMP-9 concentrations.
The systemic MMP-9 level was significantly associated with the nailfold capillaroscopy result (ρ = 0.439, p = 0.032). Of the 25 patients, seven had optic disc hemorrhage (ODH). The mean MMP-9 concentration was 4375.6 ± 2923.2 pg/ml in ODH patients and 5932.1 ± 1265.4 pg/ml in patients without ODH. However, there was no significant association of HRV parameters or disc hemorrhage with the systemic MMP-9 level.
The systemic MMP-9 level was associated with the nailfold capillaroscopy results in patients with NTG but had no direct association with ODH.
探讨正常眼压性青光眼（NTG）患者甲襞毛细血管镜检查、心率变异性（HRV）及青光眼临床特征与血浆基质金属蛋白酶-9（MMP-9）水平之间的关联。
我们对25例NTG患者进行了一项前瞻性横断面研究。排除患有全身性疾病的受试者。患者接受了全面的眼科检查，并被转诊至风湿科，在那里进行了甲襞毛细血管镜检查和HRV评估。根据HRV评估中正常到正常间期的标准差将患者分为HRV最低组和最高组。对所有受试者的血样进行MMP-9浓度检测。
全身MMP-9水平与甲襞毛细血管镜检查结果显著相关（ρ = 0.439，p = 0.032）。25例患者中，7例有视盘出血（ODH）。ODH患者的平均MMP-9浓度为4375.6±2923.2 pg/ml，无ODH患者为5932.1±1265.4 pg/ml。然而，HRV参数或视盘出血与全身MMP-9水平无显著关联。
NTG患者全身MMP-9水平与甲襞毛细血管镜检查结果相关，但与ODH无直接关联。
