Tian Jiaxin, Xie Yuan, Li Meng, Oatts Julius, Han Ying, Yang Yiquan, Shi Yan, Sun Yunxiao, Sang Jinghong, Cao Kai, Xin Chen, Siloka Labisi, Wang Huaizhou, Wang Ningli
Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.
Department of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Front Physiol. 2020 Jul 24;11:880. doi: 10.3389/fphys.2020.00880. eCollection 2020.
To evaluate whether the nailfold microcirculation is associated with retinal microcirculation in healthy subjects.
Fifty subjects without systematic and ocular diseases were enrolled. Thickness of peripapillary retinal nerve fiber layer (RNFL), vessel density (VD) of radial peripapillary capillaries (RPCs), and superficial capillary VD in macular zone were measured with optical coherence tomography angiography (OCTA) in left eyes. Nailfold microcirculation, including capillary density, avascular zones, dilated capillaries, and hemorrhages was examined on the fourth digit of each subject's non-dominant (left) hand with nailfold capillaroscopy (NFC).
After adjustment for relatively systemic factors, multivariate regression analyses showed a significant direct relationship between RNFL thickness and nailfold capillary density (OR = 1.09; = 0.046). RNFL thickness and RPCs VD were negatively correlated with nailfold avascular zones (OR = 0.855; = 0.007; OR = 0.596; = 0.010). Superficial VD of parafovea was negatively associated with dilated nailfold capillaries (OR = 0.794; = 0.012).
In healthy subjects, nailfold capillary lower density and abnormalities are associated with reduced RNFL thickness and retinal VD. The results provide a theoretical foundation for relevant studies on ocular diseases with microvascular abnormalities and could contribute to pathogenesis understanding in the future. NFC and OCTA have the potential to identify risk factors and improve accuracy of the early diagnosis and treatment of ocular diseases, even systemic diseases with any microvascular component in clinical practice.
http://www.chictr.org.cn/index.aspx, identifier ChiCTR 1800017875.
评估健康受试者甲襞微循环与视网膜微循环是否相关。
纳入50名无系统性和眼部疾病的受试者。使用光学相干断层扫描血管造影（OCTA）测量左眼视乳头周围视网膜神经纤维层（RNFL）厚度、视乳头周围放射状毛细血管（RPC）的血管密度（VD）以及黄斑区浅表毛细血管VD。用甲襞毛细血管显微镜（NFC）检查每位受试者非优势（左）手第四指的甲襞微循环，包括毛细血管密度、无血管区、扩张的毛细血管和出血情况。
在调整了相对系统性因素后，多因素回归分析显示RNFL厚度与甲襞毛细血管密度之间存在显著的直接关系（OR = 1.09；P = 0.046）。RNFL厚度和RPC的VD与甲襞无血管区呈负相关（OR = 0.855；P = 0.007；OR = 0.596；P = 0.010）。黄斑旁浅表VD与扩张的甲襞毛细血管呈负相关（OR = 0.794；P = 0.012）。
在健康受试者中，甲襞毛细血管密度降低和异常与RNFL厚度和视网膜VD降低有关。该结果为微血管异常相关眼病的相关研究提供了理论基础，并可能有助于未来对发病机制的理解。NFC和OCTA有潜力在临床实践中识别危险因素并提高眼病甚至任何具有微血管成分的全身性疾病的早期诊断和治疗准确性。
http://www.chictr.org.cn/index.aspx，标识符ChiCTR 1800017875 。
