Le Guen Emmanuel, Doukhan Raphaël, Hamdani Nora, Tamouza Ryad, Groc Laurent, Honnorat Jérôme, Leboyer Marion
Pôle psychiatrie des hôpitaux universitaires Henri Mondor, AP-HP, université Paris-Est, DHU PePSY, hôpital Albert Chenevier, 40, rue de Mesly, 94000 Créteil, France - Inserm U955, équipe 15, psychiatrie génétique, Créteil, France - fondation FondaMental, Créteil, France.
laboratoire Jean Dausset d'immunologie et d'histocompatibilité, hôpital Saint Louis, Paris, France - LabEx Transplantex, Inserm UMRS 1160, Paris, France - université Paris Diderot, Paris, France.
Med Sci (Paris). 2015 Jan;31(1):60-7. doi: 10.1051/medsci/20153101014. Epub 2015 Feb 6.
The recent discovery of anti-NMDA receptor antibodies and proof of their pathogenic effects in limbic encephalitides raised many questions among neuroscientist and physicians working in the field of schizophrenia. Indeed, this two conditions share several major clinical, pathophysiological or etiological aspects and some authors tend to consider some forms of schizophrenia as mild-encephalitis cases. Some studies have reported the presence of these antibodies in schizophrenic patient's sera without neurological symptoms. These findings suggest new therapeutic perspectives in some schizophrenic patients, despite a low seroprevalence and pathogenic effects that remain to be demonstrated.
近期抗N-甲基-D-天冬氨酸（NMDA）受体抗体的发现及其在边缘性脑炎中致病作用的证实，在精神分裂症领域工作的神经科学家和医生中引发了诸多问题。事实上，这两种病症在临床、病理生理或病因学等多个主要方面存在共性，一些作者倾向于将某些形式的精神分裂症视为轻度脑炎病例。一些研究报告称，在没有神经症状的精神分裂症患者血清中存在这些抗体。尽管血清阳性率较低且致病作用仍有待证实，但这些发现为部分精神分裂症患者提供了新的治疗前景。
