Martins Sylvie, Guillery-Girard Bérengère, Clochon Patrice, Bulteau Christine, Hertz-Pannier Lucie, Chiron Catherine, Eustache Francis, Jambaqué Isabelle
UMR-S1077, INSERM, Université de Caen Basse-Normandie, Ecole Pratique des Hautes Etudes, CHU de Caen, France; INSERM U1129, Paris, France; Université Paris Descartes, PRES Sorbonne Paris Cité, France; CEA, Gif sur Yvette, France; UNIACT, Neuropsin, CEA-Sacley, France.
UMR-S1077, INSERM, Université de Caen Basse-Normandie, Ecole Pratique des Hautes Etudes, CHU de Caen, France.
Epilepsy Behav. 2015 Mar;44:86-9. doi: 10.1016/j.yebeh.2015.01.008. Epub 2015 Feb 4.
While the current literature on children suffering from temporal lobe epilepsy (CTLE) mostly focuses on material-related episodic memory deficits according to seizure-onset lateralization, the present study examined associative episodic memory according to the type of information to memorize (e.g., factual, spatial, and sequential) and further investigated subjective and objective recollection. Eleven children with left temporal lobe epilepsy (LTLE), 10 children with right temporal lobe epilepsy (RTLE), among whom 9 displayed hippocampal sclerosis (HS), and 42 healthy controls completed the WHAT-WHEN-WHERE protocol (Guillery-Girard et al., 2013). Group comparisons were first conducted according to the affected side and second according to the underlying pathology. Results showed associative memory impairments in patients irrespective of the affected side. Moreover, this study revealed that HS is particularly deleterious to associative and subjective recollection in CTLE. In addition, this study emphasizes the need for assessing episodic memory in childhood TLE beyond material specificity.
虽然目前关于颞叶癫痫患儿（CTLE）的文献大多根据癫痫发作起始侧化情况聚焦于与物质相关的情景记忆缺陷，但本研究根据要记忆的信息类型（如实事、空间和顺序）对联想情景记忆进行了研究，并进一步调查了主观和客观回忆。11名左侧颞叶癫痫（LTLE）患儿、10名右侧颞叶癫痫（RTLE）患儿（其中9名有海马硬化（HS））以及42名健康对照完成了“何事-何时-何地”方案（Guillery-Girard等人，2013年）。首先根据患侧进行组间比较，其次根据潜在病理情况进行比较。结果显示，无论患侧如何，患者均存在联想记忆障碍。此外，本研究表明，HS对CTLE患者的联想和主观回忆尤其有害。此外，本研究强调，除了物质特异性之外，评估儿童颞叶癫痫的情景记忆也很有必要。
