Pinjuh Markota Nina, Rumboldt Mirjana, Rumboldt Zvonko
Department of Family Medicine, Mostar University School of Medicine, Mostar, Bosnia and Herzegovina.
Department of Family Medicine, Split University School of Medicine, Split, Croatia.
J Am Soc Hypertens. 2015 Mar;9(3):214-20. doi: 10.1016/j.jash.2014.12.022. Epub 2015 Jan 6.
Excessive salt intake is a major cardiovascular risk factor. At variance to the developed countries, the main source of sodium in transitional and developing countries is salt added while cooking and/or at the table. The objective of this trial was to examine the impact of warning labels placed on home salt containers on daily salt intake.A sample of treated hypertensives (n = 150) was randomized in two subgroups, one receiving just a leaflet about the harmful effects of excessive salt intake (control; n = 74), and the other one receiving in addition warning stickers for household salt containers (intervention; n = 76). Arterial blood pressure (BP) and 24-hour urinary sodium excretion (Na24) were measured in all the subjects at the start of the trial, and 1 month and 2 months later. The average starting Na24 was 207 ± 71 mmol in the control group and 211 ± 85 mmol in the intervention group (P = .745). One month and 2 months later, a significant decrease was observed in the intervention group (to 183 ± 63 mmol and 176 ± 55 mmol; P < .0001), as opposed to the control group (203 ± 60 mmol and 200 ± 58 mmol; P = .1466). Initial BP was 143.7/84.1 mm Hg in the control, and 142.9/84.7 mm Hg in the intervention group (P = .667). One month and 2 months later, a significant drop in BP, by 5.3/2.9 mm Hg, was observed in the intervention group as opposed to the control group (0.4/0.9 mm Hg). Decrease in Na24 positively correlated to BP lowering (r(2) = 0.5989; P < .0001). A significant reduction in 24Na and BP is achieved with warning labels on harmful effects of excessive salt intake. Decreasing daily salt input by 35 mmol may result in an extra BP lowering by some 5-6/2-3 mm Hg.
过量摄入盐是主要的心血管危险因素。与发达国家不同,转型期国家和发展中国家钠的主要来源是烹饪时和/或就餐时添加的盐。本试验的目的是研究在家用盐容器上张贴警示标签对每日盐摄入量的影响。选取了150例高血压患者作为样本,随机分为两个亚组,一组仅收到一份关于过量摄入盐有害影响的传单(对照组,n = 74),另一组除了收到传单外,还在家用盐容器上贴上警示标签(干预组,n = 76)。在试验开始时、1个月后和2个月后,对所有受试者测量动脉血压(BP)和24小时尿钠排泄量(Na24)。对照组的平均初始Na24为207±71 mmol,干预组为211±85 mmol(P = 0.745)。1个月和2个月后,干预组的Na24显著下降(降至183±63 mmol和176±55 mmol;P < 0.0001),而对照组则为(203±60 mmol和200±58 mmol;P = 0.1466)。对照组的初始血压为143.7/84.1 mmHg,干预组为142.9/84.7 mmHg(P = 0.667)。1个月和2个月后,干预组的血压显著下降了5.3/2.9 mmHg,而对照组仅下降了0.4/0.9 mmHg。Na24的下降与血压降低呈正相关(r(2) = 0.5989;P < 0.0001)。通过张贴关于过量摄入盐有害影响的警示标签,24小时尿钠排泄量和血压显著降低。每日盐摄入量减少35 mmol可能会使血压额外降低约5 - 6/2 - 3 mmHg。