来自新喀里多尼亚栀子属植物（茜草科）的天然和半合成类黄酮的抗血管生成和抗寄生虫活性。
Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
机构信息
Laboratoire de Pharmacognosie, UMR/CNRS 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
Laboratoire de Pharmacologie Chimique, Génétique et Imagerie U1022 Inserm-UMR8151 CNRS, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4, Avenue de l'Observatoire, 75006 Paris, France.
出版信息
Eur J Med Chem. 2015 Mar 26;93:93-100. doi: 10.1016/j.ejmech.2015.01.012. Epub 2015 Jan 8.
A series of 16 flavonoids were isolated and prepared from bud exudate of Gardenia urvillei and Gardenia oudiepe, endemic to New Caledonia. Most of them are rare polymethoxylated flavones. Some of these compounds showed noticeable activity against Leishmania (Leishmania) amazonensis, Plasmodium falciparum and Trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. We also provide a full set of NMR data as some of the flavones were incompletely described.
从新喀里多尼亚特有物种 Gardenia urvillei 和 Gardenia oudiepe 的芽渗出液中分离并制备了一系列 16 种类黄酮。它们大多数是罕见的多甲氧基黄酮。除了在低微摩尔浓度下抑制微管聚合外，其中一些化合物对利什曼原虫（Leishmania）amazonensis、恶性疟原虫和冈比亚锥虫也显示出明显的活性。我们还提供了一整套 NMR 数据，因为其中一些类黄酮的描述并不完整。
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