Masuda K, Nakajima A, Urayama A, Nakae K, Kogure M, Inaba G
Department of Ophthalmology, Faculty of Medicine, University of Tokyo, School of Medicine, Japan.
Lancet. 1989 May 20;1(8647):1093-6. doi: 10.1016/s0140-6736(89)92381-7.
The efficacy and safety of oral cyclosporin 10 mg/kg per day in Behçet's disease were compared in a randomised double-masked study with those of colchicine, 1 mg orally per day, and were also investigated in a long-term open study. The double-masked study showed that cyclosporin was effective in treating not only the ocular manifestations of Behçet's disease but also oral aphthous ulcer, dermal lesions, and genital ulceration. Efficacy did not weaken during long-term treatment.
在一项随机双盲研究中，对比了每天口服10毫克/千克环孢素治疗白塞病的疗效和安全性与每天口服1毫克秋水仙碱的疗效和安全性，并且还在一项长期开放研究中进行了调查。双盲研究表明，环孢素不仅对白塞病的眼部表现有效，而且对口腔溃疡、皮肤病变和生殖器溃疡也有效。长期治疗期间疗效并未减弱。
