环孢素A短期治疗白塞病。
Short term cyclosporin A treatment of Behçet's disease.
作者信息
Müftüoğlu A U, Pazarli H, Yurdakul S, Yazici H, Ulkü B Y, Tüzün Y, Serdaroğlu S, Altuğ E, Bahçecioğlu H, Güngen G
出版信息
Br J Ophthalmol. 1987 May;71(5):387-90. doi: 10.1136/bjo.71.5.387.
Abstract
Eleven separate three-month courses of cyclosporin A, an oral solution 10 mg/kg/day, were administered to eight patients with Behçet's disease with sight-threatening posterior uveitis. It was found to be effective in arresting the inflammatory activity in the eye as well as the mucocutaneous lesions of Behçet's disease. Improvement in visual acuity was observed within one week of starting therapy. Severe exacerbations in the ocular and mucocutaneous lesions occurred on withdrawal of the drug. At this dosage side effects included hirsutism in all women, and a slight rise of serum bilirubins in two patients and of blood urea in one patient. The latter two conditions responded rapidly to dose adjustment.
摘要
对8例患有威胁视力的后葡萄膜炎的白塞病患者，给予11个为期3个月的单独疗程的环孢素A（口服溶液，10毫克/千克/天）治疗。结果发现，它对于抑制眼部的炎症活动以及白塞病的黏膜皮肤病变有效。在开始治疗的一周内观察到视力有所改善。停药后眼部和黏膜皮肤病变出现严重恶化。在此剂量下，副作用包括所有女性均出现多毛症，2例患者血清胆红素略有升高，1例患者血尿素升高。后两种情况通过调整剂量迅速得到缓解。
相似文献
1
Short term cyclosporin A treatment of Behçet's disease.环孢素A短期治疗白塞病。
Br J Ophthalmol. 1987 May;71(5):387-90. doi: 10.1136/bjo.71.5.387.
2
Cyclosporin A treatment of Behçet's disease: a long-term study.
Curr Eye Res. 1990;9 Suppl:17-23. doi: 10.3109/02713689008999414.
3
Cyclosporin A in the treatment of severe Behçet's uveitis.
Br J Rheumatol. 1987 Aug;26(4):285-91. doi: 10.1093/rheumatology/26.4.285.
4
Double-masked trial of cyclosporin versus colchicine and long-term open study of cyclosporin in Behçet's disease.环孢素与秋水仙碱的双盲试验及环孢素治疗白塞病的长期开放性研究。
Lancet. 1989 May 20;1(8647):1093-6. doi: 10.1016/s0140-6736(89)92381-7.
5
Effectiveness of cyclosporin therapy for Behçet's disease.
Arthritis Rheum. 1985 Jun;28(6):671-9. doi: 10.1002/art.1780280611.
6
Treatment of intraocular inflammatory disease with cyclosporin A.用环孢素A治疗眼内炎性疾病。
Lancet. 1983 Jul 30;2(8344):235-8. doi: 10.1016/s0140-6736(83)90230-1.
7
[Therapy of the ocular form of Behçet disease with cyclosporin A].[用环孢素A治疗白塞病的眼部病变]
Klin Monbl Augenheilkd. 1990 Jun;196(6):466-9. doi: 10.1055/s-2008-1046225.
8
Cyclosporin A in the treatment of posterior uveitis.
Trans Ophthalmol Soc U K (1962). 1985;104 ( Pt 2):146-51.
9
Cyclosporine in Behçet's disease resistant to conventional therapy.
Ann Ophthalmol. 1989 Mar;21(3):111-6, 118.
10
[Behçet's disease].[白塞病]
Ned Tijdschr Geneeskd. 1987 Sep 5;131(36):1585-6.
引用本文的文献
1
A Clinical Picture of the Visual Outcome in Adamantiades-Behçet's Disease.白塞病视觉预后的临床情况
Biomed Res Int. 2015;2015:120519. doi: 10.1155/2015/120519. Epub 2015 Oct 19.
2
Update on the therapy of Behçet disease.白塞病治疗的最新进展。
Ther Adv Chronic Dis. 2014 May;5(3):112-34. doi: 10.1177/2040622314523062.
3
Cyclosporin-A associated malignancy.环孢素A相关恶性肿瘤。
Clin Ophthalmol. 2007 Dec;1(4):421-30.
4
Long-term therapy with low dose cyclosporin A in ocular Behçet's disease.低剂量环孢素A治疗眼部白塞病的长期疗效
Doc Ophthalmol. 2002 Nov;105(3):301-12. doi: 10.1023/a:1021227019915.
5
Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders.环孢素。对其药效学和药代动力学特性以及在免疫调节紊乱中的治疗应用的综述。
Drugs. 1993 Jun;45(6):953-1040. doi: 10.2165/00003495-199345060-00007.
6
Adverse reactions and interactions of cyclosporin.环孢素的不良反应及相互作用。
Med Toxicol Adverse Drug Exp. 1988 Mar-Apr;3(2):107-27. doi: 10.1007/BF03259936.
7
Immunosuppressive drugs and corticosteroids in the treatment of rheumatoid arthritis.免疫抑制药物和皮质类固醇在类风湿性关节炎治疗中的应用
Drugs. 1988 Sep;36(3):340-63. doi: 10.2165/00003495-198836030-00005.
8
Cyclosporin in the treatment of severe chronic idiopathic uveitis.环孢素治疗重度慢性特发性葡萄膜炎。
Br J Ophthalmol. 1990 Jun;74(6):344-9. doi: 10.1136/bjo.74.6.344.
9
Cyclosporine effects on optic nerve and retinal vasculitis in Behçet's disease.
Doc Ophthalmol. 1992;80(2):133-42. doi: 10.1007/BF00161239.
10
Low dose cyclosporin A versus pulsed cyclophosphamide in Behçet's syndrome: a single masked trial.低剂量环孢素A与脉冲式环磷酰胺治疗白塞病的疗效比较：一项单盲试验
Br J Ophthalmol. 1992 Apr;76(4):241-3. doi: 10.1136/bjo.76.4.241.
本文引用的文献
1
Polyarthritis in Behcet's multiple symptom complex.白塞氏多症状综合征中的多关节炎
Ann Rheum Dis. 1963 Jan;22(1):26-35. doi: 10.1136/ard.22.1.26.
2
The combined use of HLA-B5 and the pathergy test as diagnostic markers of Behçet's disease in Turkey.在土耳其，HLA - B5与针刺反应试验联合应用作为白塞病的诊断标志物。
J Rheumatol. 1980 Mar-Apr;7(2):206-10.
3
Cellular immune responsiveness of uveitis patients to retinal S-antigen.葡萄膜炎患者对视网膜S抗原的细胞免疫反应性。
Am J Ophthalmol. 1980 Feb;89(2):173-9. doi: 10.1016/0002-9394(80)90108-7.
4
Summary of the Third International Conference on Behçet's Disease, Tokyo, Japan, October 23-24, 1981.1981年10月23日至24日于日本东京召开的第三届白塞病国际会议总结
J Rheumatol. 1983 Feb;10(1):154-8.
5
Inhibition of T-cell activity by cyclosporin A.环孢菌素A对T细胞活性的抑制作用。
Scand J Immunol. 1981 May;15(5):449-58. doi: 10.1111/j.1365-3083.1982.tb00670.x.
6
Cyclosporin A. Clinical pharmacology and therapeutic potential.
Drugs. 1982 Oct;24(4):322-34. doi: 10.2165/00003495-198224040-00004.
7
Cyclosporin A therapy in the treatment of intraocular inflammatory disease resistant to systemic corticosteroids and cytotoxic agents.环孢素A治疗对全身用皮质类固醇和细胞毒性药物耐药的眼内炎性疾病。
Am J Ophthalmol. 1983 Sep;96(3):275-82. doi: 10.1016/s0002-9394(14)77814-6.
8
Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.环孢素A通过损害白细胞介素1和白细胞介素2的释放来介导对原发性细胞毒性T细胞反应的免疫抑制。
Eur J Immunol. 1981 Aug;11(8):657-61. doi: 10.1002/eji.1830110812.
9
Treatment of intraocular inflammatory disease with cyclosporin A.用环孢素A治疗眼内炎性疾病。
Lancet. 1983 Jul 30;2(8344):235-8. doi: 10.1016/s0140-6736(83)90230-1.
10
Behçet's disease. Report of twelve cases with three manifesting as papilledema.白塞病。12例报告，其中3例表现为视乳头水肿。
Am J Med. 1970 Dec;49(6):823-9. doi: 10.1016/s0002-9343(70)80064-x.
Zotero 插件