Leduc Cécile, Etienne-Manneville Sandrine
Institut Pasteur - CNRS UMR 3691, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.
Institut Pasteur - CNRS UMR 3691, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.
Curr Opin Cell Biol. 2015 Feb;32:102-12. doi: 10.1016/j.ceb.2015.01.005. Epub 2015 Feb 6.
Cell migration is a multistep process which relies on the coordination of cytoskeletal structures in space and time. While the roles of actin and microtubules have been investigated in great details, the lack of inhibitors and visualizing tools and the large number of proteins forming intermediate filaments (IFs) have delayed the characterization of IF functions during migration. However, a large body of evidence has progressively pointed to changes in IF composition as an important parameter in the regulation of cell migratory properties both during development and tumor invasion. More recent in-depth analyses show that IFs are dynamically reorganized to participate, together with microfilaments and microtubules, to the key steps leading to cell migration.
细胞迁移是一个多步骤过程，它依赖于细胞骨架结构在空间和时间上的协调。虽然肌动蛋白和微管的作用已得到详细研究，但由于缺乏抑制剂和可视化工具，以及形成中间丝（IFs）的蛋白质数量众多，阻碍了对迁移过程中IF功能的表征。然而，大量证据逐渐表明，IF组成的变化是发育和肿瘤侵袭过程中调节细胞迁移特性的一个重要参数。最近的深入分析表明，IFs会动态重组，与微丝和微管一起参与导致细胞迁移的关键步骤。
