Tang Dale D
Department of Molecular and Cellular Physiology, Albany Medical College, New York, USA.
Results Probl Cell Differ. 2025;75:73-89. doi: 10.1007/978-3-031-91459-1_3.
The cytoskeleton of eukaryotic cells undergoes a reorganization in response to intracellular and extracellular cues, which plays an essential role in orchestrating various cell functions including migration, development, differentiation, tissue homeostasis, contractility, proliferation, gene expression, cancer cell invasion, and airway/vascular remodeling. Acetylation occurs on the cytoskeletal components, such as microtubules, actin, and vimentin, which regulate cellular functions. Moreover, remodeling of the cytoskeleton is regulated by acetylation and deacetylation of regulatory proteins, including adapter proteins and protein kinases. Therefore, protein acetylation and deacetylation are critical mechanisms for cytoskeletal reorganization in response to changes of intracellular and extracellular environments.
真核细胞的细胞骨架会根据细胞内和细胞外信号发生重组，这在协调包括迁移、发育、分化、组织稳态、收缩性、增殖、基因表达、癌细胞侵袭以及气道/血管重塑等各种细胞功能中起着至关重要的作用。乙酰化发生在细胞骨架成分上，如微管、肌动蛋白和波形蛋白，这些成分调节细胞功能。此外，细胞骨架的重塑由调节蛋白（包括衔接蛋白和蛋白激酶）的乙酰化和去乙酰化调节。因此，蛋白质乙酰化和去乙酰化是细胞骨架响应细胞内和细胞外环境变化而重组的关键机制。
