Blanco Ulla M, López Carballeira A, Pumar Cebreiro J M
Servicio de Radiología. Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, España.
Servicio de Radiología. Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, España.
Radiologia. 2015 Nov-Dec;57(6):505-11. doi: 10.1016/j.rx.2014.12.008. Epub 2015 Feb 7.
To review the pathophysiologic mechanisms involved in hypertrophic olivary degeneration, with attention to epidemiologic and clinical aspects and especially to imaging findings.
We reviewed 5 patients diagnosed with hypertrophic olivary degeneration at our center from 2010 through 2013, analyzing relevant clinical, epidemiologic, and radiologic findings.
In all cases, a hyperintensity was seen in the inferior olivary nuclei in FLAIR and T2-weighted sequences. No signal alterations were seen on T1-weighted sequences, and no enhancement was seen after intravenous injection of contrast material. In the cases studied by diffusion-weighted imaging, no significant alterations were seen in these sequences. Olivary hypertrophy was seen in all patients except in one, in whom presumably not enough time had elapsed for hypertrophy to occur. The alterations were bilateral in two of the five cases. Only one case exhibited the typical clinical manifestations.
Given that patients may not present clinical manifestations that can be attributed to hypertrophic olivary degeneration, it is important to recognize the characteristic radiologic signs of this entity.
回顾与肥大性橄榄核变性相关的病理生理机制，关注流行病学和临床方面，尤其是影像学表现。
我们回顾了2010年至2013年在我们中心诊断为肥大性橄榄核变性的5例患者，分析相关的临床、流行病学和放射学表现。
在所有病例中，液体衰减反转恢复序列（FLAIR）和T2加权序列上可见下橄榄核高信号。T1加权序列未见信号改变，静脉注射对比剂后未见强化。在采用扩散加权成像研究的病例中，这些序列未见明显改变。除1例患者外，其余患者均可见橄榄核肥大，推测该例患者时间间隔不足，尚未发生肥大。5例中有2例改变为双侧性。仅1例表现出典型临床表现。
鉴于患者可能未出现可归因于肥大性橄榄核变性的临床表现，认识该疾病的特征性放射学征象很重要。
