AGT基因中的M235T多态性和REN基因中的A/G（I8-83）替换与终末期肾病相关。

M235T polymorphism in the AGT gene and A/G(I8-83) substitution in the REN gene correlate with end-stage renal disease.

作者信息

Sarkar Saumya, Gupta Vikas, Kumar Ajay, Chaudhary Manoj, Diyundi Subhash, Sehajpal Prabodh K, Thangaraj Kumarasamy, Rajender Singh

机构信息

Division of Endocrinology, Central Drug Research Institute, Lucknow, India.

出版信息

Nephron. 2015;129(2):104-8. doi: 10.1159/000370074. Epub 2015 Jan 31.

DOI:10.1159/000370074

PMID:25660845

Abstract

BACKGROUND/AIMS: This study aimed at investigating if M235T polymorphism in the AGT gene and A/G(I8-83) polymorphism in the REN gene correlate with end-stage renal disease (ESRD).

METHODS

We analyzed 173 ESRD patients and 329 individuals with normal kidney function for differences in the genotype distribution of AGT-M235T and REN-A/G(I8-83) polymorphisms between the two groups. The data for cases and controls were compared using the χ(2) test.

RESULTS

We found significantly higher levels of serum creatinine and CRP in cases in comparison to controls (p < 0.0001). Data comparison showed a significant association of AGT M235T substitution with ESRD in the dominant model (p = 0.008) and in the comparison of the heterozygous substitution with the homozygous common genotype (p = 0.005). Similarly, REN A/G(I8-83) polymorphism showed a significant difference in the distribution of genotypes between cases and controls (p < 0.038) such that a heterozygous substitution was significantly more common in the ESRD cases in comparison to the homozygous common genotype (p = 0.023).

CONCLUSION

We conclude that heterozygous substitutions at the AGT M235T and REN A/G(I8-83) loci correlate significantly with ESRD in a north Indian population.

摘要

背景/目的：本研究旨在调查血管紧张素原（AGT）基因中的M235T多态性和肾素（REN）基因中的A/G（I8-83）多态性是否与终末期肾病（ESRD）相关。

方法

我们分析了173例ESRD患者和329例肾功能正常的个体，比较两组之间AGT-M235T和REN-A/G（I8-83）多态性的基因型分布差异。使用χ²检验比较病例组和对照组的数据。

结果

我们发现病例组的血清肌酐和CRP水平显著高于对照组（p < 0.0001）。数据比较显示，在显性模型中，AGT M235T替代与ESRD显著相关（p = 0.008），杂合替代与纯合常见基因型比较时也显著相关（p = 0.005）。同样，REN A/G（I8-83）多态性在病例组和对照组之间的基因型分布存在显著差异（p < 0.038），即与纯合常见基因型相比，杂合替代在ESRD病例中显著更常见（p = 0.023）。