Sabot C, Pechadre J C, Beudin P, Lauxerois M, Trolese J F, Kantelip J P, Ducher J L, Gibert J
Laboratoire d'électroencéphalographie, Exploration fonctionnelle du système nerveux, Hôtel-Dieu, Clermont-Ferrand, France.
Neurophysiol Clin. 1989 Mar;19(1):55-64. doi: 10.1016/s0987-7053(89)80085-1.
The effects of five beta blockers on the central nervous system of healthy subjects was studied by computerized EEG analysis. All subjects underwent continuous recording with a Holter magnetic type recorder during the experimental period. For 10 consecutive days, five groups of subjects received alternately placebo and the beta blockers acebutolol 600 mg, carteolol 20 mg, metoprolol 200 mg, pindolol 30 mg and sotalol 320 mg. EEG recordings (C4/P4, P4/02 and C3/P3, P3/01) lasting 5 min were made between 8.30 and 9.30 a.m. Subjects were at rest with eyes closed and there was no vigilance control. The signal was recorded on a magnetic tape recorder and then processed by Nicolet MED 80 system. Comparisons of absolute and relative powers and of average frequencies were then made between the different sequences and groups. The possible correlations between the changes observed in the power spectrum and the clinical, pharmacological and pharmacokinetic specific properties of each beta blocker are discussed.
通过计算机脑电图分析研究了五种β受体阻滞剂对健康受试者中枢神经系统的影响。在实验期间，所有受试者均使用动态心电图磁式记录仪进行连续记录。连续10天，五组受试者交替服用安慰剂和β受体阻滞剂醋丁洛尔600毫克、卡替洛尔20毫克、美托洛尔200毫克、吲哚洛尔30毫克和索他洛尔320毫克。在上午8点30分至9点30分之间进行持续5分钟的脑电图记录（C4/P4、P4/02以及C3/P3、P3/01）。受试者闭眼休息，未进行警觉性控制。信号记录在磁带记录仪上，然后由Nicolet MED 80系统进行处理。随后对不同序列和组之间的绝对功率、相对功率以及平均频率进行比较。讨论了在功率谱中观察到的变化与每种β受体阻滞剂的临床、药理和药代动力学特性之间可能存在的相关性。
