Nahin R L, Hylden J L, Iadarola M J, Dubner R
Neurobiology and Anesthesiology Branch, National Institute of Dental Research, Bethesda, MD 20892.
Neurosci Lett. 1989 Jan 30;96(3):247-52. doi: 10.1016/0304-3940(89)90386-8.
The present study combined the retrograde transport of fluorescent tracers with the immunocytochemical identification of dynorphin A(1-8) in superficial dorsal horn neurons to examine whether peripheral inflammation-induced dynorphin increases are found in local circuit neurons only or also in neurons projecting at least to the caudal mesencephalon. Evidence is presented that complete Freund's adjuvant-induced inflammation produces a large increase in the number of lamina I dynorphin-containing projection and non-projection neurons, and in the number of lamina II dynorphin local circuit neurons.
本研究将荧光示踪剂的逆行运输与浅背角神经元中强啡肽A（1-8）的免疫细胞化学鉴定相结合，以检查外周炎症诱导的强啡肽增加是否仅在局部回路神经元中出现，还是也出现在至少投射到中脑尾部的神经元中。有证据表明，完全弗氏佐剂诱导的炎症会使I层含强啡肽的投射神经元和非投射神经元数量大幅增加，以及II层强啡肽局部回路神经元数量大幅增加。
