Takahashi O, Traub R J, Ruda M A
Neurobiology and Anesthesiology Branch, National Institute of Dental Research, Bethesda, MD 20892.
Brain Res. 1988 Dec 13;475(1):168-72. doi: 10.1016/0006-8993(88)90213-2.
In a rat model of peripheral inflammation and hyperalgesia, dynorphin A(1-8)-like immunoreactive (DYN-LIr) spinal neurons were examined for contacts from calcitonin gene-related peptide-like immunoreactive (CGRP-LIr) varicosities using a double-label PAP method. Ipsilateral to the inflammation, CGRP-LIr varicosities contacted both dendrites and somata of DYN-LIr neurons in lumbar laminae I, II and V. Few such contacts were found on the contralateral side. The results suggest that opioid neurons which exhibit a dynamic change in dynorphin associated with inflammation, represent a subpopulation of neurons that receive contacts from presumptive nociceptive primary afferents.
在一个外周炎症和痛觉过敏的大鼠模型中，使用双标记过氧化物酶抗过氧化物酶（PAP）法，检查了强啡肽A（1-8）样免疫反应性（DYN-LIr）脊髓神经元与降钙素基因相关肽样免疫反应性（CGRP-LIr）曲张体的接触情况。在炎症同侧，CGRP-LIr曲张体与腰I、II和V层中DYN-LIr神经元的树突和胞体均有接触。在对侧则很少发现这种接触。结果表明，与炎症相关的强啡肽表现出动态变化的阿片样物质神经元，代表了接受假定伤害性初级传入纤维接触的神经元亚群。
