Roten Amanda, Baker Nathaniel L, Gray Kevin M
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, 125 Doughty Street, Suite 190, MSC 861, Charleston, SC 29425, United States.
Medical University of South Carolina, Department of Public Health Sciences, 135 Cannon Street, MSC 835, Charleston, SC 29425, United States.
Addict Behav. 2015 Jun;45:119-23. doi: 10.1016/j.addbeh.2015.01.013. Epub 2015 Jan 23.
Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance.
This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery.
Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores.
These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.
青少年使用大麻与神经认知障碍有关，但需要进一步研究来评估与治疗相关的戒断与认知表现之间的关系。
这项二次分析是在一项青少年大麻戒断药物治疗试验的背景下进行的，使用中枢神经系统生命体征评估量表在基线以及治疗期间的两个时间点检查认知表现。
通过尿液大麻素检测评估，相对于继续使用大麻，戒断大麻与综合记忆（p<0.001）、言语记忆（综合记忆中受影响最大的部分）（p<0.001）和精神运动表现（p=0.045）得分的显著改善有关。
这些发现表明，即使在与治疗相关的戒断早期阶段，某些认知表现领域也会显著改善。
