一项针对大麻依赖青少年的安慰剂对照药物治疗试验中的认知表现。
Cognitive performance in a placebo-controlled pharmacotherapy trial for youth with marijuana dependence.
作者信息
Roten Amanda, Baker Nathaniel L, Gray Kevin M
机构信息
Medical University of South Carolina, Department of Psychiatry and Behavioral Sciences, 125 Doughty Street, Suite 190, MSC 861, Charleston, SC 29425, United States.
Medical University of South Carolina, Department of Public Health Sciences, 135 Cannon Street, MSC 835, Charleston, SC 29425, United States.
出版信息
Addict Behav. 2015 Jun;45:119-23. doi: 10.1016/j.addbeh.2015.01.013. Epub 2015 Jan 23.
Abstract
BACKGROUND
Adolescent marijuana use is associated with neurocognitive impairment, but further work is needed to assess the relationship between treatment-associated abstinence and cognitive performance.
METHODS
This secondary analysis, conducted in the context of a marijuana cessation pharmacotherapy trial in adolescents, examined cognitive performance at baseline and at two time points during treatment using the CNS Vital Signs assessment battery.
RESULTS
Abstinence from marijuana, relative to continued use, as assessed via urine cannabinoid testing, was associated with significant improvement in composite memory (p<0.001), verbal memory (the most impacted component of composite memory) (p<0.001), and psychomotor performance (p=0.045) scores.
CONCLUSIONS
These findings suggest that some domains of cognitive performance improve significantly even in the early stages of treatment-associated abstinence.
摘要
背景
青少年使用大麻与神经认知障碍有关，但需要进一步研究来评估与治疗相关的戒断与认知表现之间的关系。
方法
这项二次分析是在一项青少年大麻戒断药物治疗试验的背景下进行的，使用中枢神经系统生命体征评估量表在基线以及治疗期间的两个时间点检查认知表现。
结果
通过尿液大麻素检测评估，相对于继续使用大麻，戒断大麻与综合记忆（p<0.001）、言语记忆（综合记忆中受影响最大的部分）（p<0.001）和精神运动表现（p=0.045）得分的显著改善有关。
结论
这些发现表明，即使在与治疗相关的戒断早期阶段，某些认知表现领域也会显著改善。
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1
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Addict Behav. 2013 Mar;38(3):1788-91. doi: 10.1016/j.addbeh.2012.11.003. Epub 2012 Nov 16.
2
Acute lorazepam effects on neurocognitive performance.急性劳拉西泮对神经认知表现的影响。
Epilepsy Behav. 2012 Nov;25(3):329-33. doi: 10.1016/j.yebeh.2012.08.019. Epub 2012 Oct 24.
3
Persistent cannabis users show neuropsychological decline from childhood to midlife.持续吸食大麻的人从儿童期到中年会出现神经认知能力下降。
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):E2657-64. doi: 10.1073/pnas.1206820109. Epub 2012 Aug 27.
4
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6
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Behav Brain Res. 2010 Dec 20;215(1):45-57. doi: 10.1016/j.bbr.2010.06.023. Epub 2010 Jun 25.
7
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Drug Alcohol Depend. 2009 Jun 1;102(1-3):35-40. doi: 10.1016/j.drugalcdep.2008.12.010. Epub 2009 Feb 13.
8
Neuropsychological functioning in adolescent marijuana users: subtle deficits detectable after a month of abstinence.青少年大麻使用者的神经心理功能：戒断一个月后可检测到细微缺陷。
J Int Neuropsychol Soc. 2007 Sep;13(5):807-20. doi: 10.1017/S1355617707071032.
9
Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs.计算机化神经认知测试组合CNS Vital Signs的信度和效度。
Arch Clin Neuropsychol. 2006 Oct;21(7):623-43. doi: 10.1016/j.acn.2006.05.007. Epub 2006 Oct 2.
10
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Neurotoxicol Teratol. 2005 Mar-Apr;27(2):231-9. doi: 10.1016/j.ntt.2004.11.003. Epub 2004 Dec 9.
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