Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
Department of Psychiatry, University of California, San Diego, San Diego, CA, USA.
J Int Neuropsychol Soc. 2020 Sep;26(8):776-784. doi: 10.1017/S1355617720000260. Epub 2020 Apr 20.
Previous research suggests recovery from cannabis-related deficits in verbal learning and memory functioning after periods of cannabis abstinence in adolescents. Here, we examine how cannabis cessation affects cognitive performance over 2 weeks of monitored abstinence compared to controls in adolescents and young adults.
Seventy-four participants (35 cannabis users) aged 16-26 ceased all cannabis, alcohol, and other illicit substance consumption for a 2-week period; abstinence was monitored via weekly urinalysis, breath, and sweat patch testing. Starting at baseline, participants completed weekly abbreviated neuropsychological batteries. Measures included tests of attention, inhibition, verbal working memory, and learning. Repeated measures assessed within and between subject effects for time and group status, while controlling for past year alcohol and nicotine use.
Cannabis users showed increased performance compared to controls on sustained attention tasks after 2 weeks of cannabis use.
Deficits in attention, but not verbal learning and memory, recovered after 2 weeks of monitored abstinence. This differs from previous literature, suggesting that other cognitive domains may show signs of recovery after periods of cannabis cessation in adolescents and young adults.
先前的研究表明，青少年在停止吸食大麻一段时间后，其与语言学习和记忆功能相关的恢复情况。在此，我们研究了与对照组相比，在 2 周的监测性禁欲期间，大麻戒断如何影响认知表现，参与者为青少年和年轻人。
74 名参与者（35 名大麻使用者）年龄在 16-26 岁之间，他们停止了所有大麻、酒精和其他非法物质的消费，为期 2 周；通过每周尿检、呼气和汗液贴片测试来监测禁欲情况。从基线开始，参与者每周完成简短的神经心理测试。测试包括注意力、抑制、语言工作记忆和学习等方面。重复测量评估了时间和组间的影响，同时控制了过去一年的酒精和尼古丁使用情况。
大麻使用者在 2 周的大麻使用后，在持续注意力任务上的表现优于对照组。
在经过 2 周的监测性禁欲后，注意力缺陷得到了恢复，但语言学习和记忆缺陷没有得到恢复。这与之前的文献不同，表明在青少年和年轻人停止吸食大麻一段时间后，其他认知领域可能会出现恢复迹象。
