Blaževski Jana, Petković Filip, Momčilović Miljana, Jevtić Bojan, Mostarica Stojković Marija, Miljković Djordje
Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Serbia.
Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Serbia.
Immunobiology. 2015 Jul;220(7):845-50. doi: 10.1016/j.imbio.2015.01.007. Epub 2015 Jan 22.
It has been increasingly appreciated that tumor necrosis factor (TNF) performs various protective and anti-inflammatory functions in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Recently, CXCL12 has been identified as a key inhibitor of leukocyte entry into the central nervous system (CNS) and as a regulator of inflammation resulting from the invasion. Here, a positive correlation between expression of TNF and CXCL12 in the CNS samples of EAE rats is presented. Also, it is shown that TNF potentiates CXCL12 expression in astrocytes. These results contribute to a view that TNF produced within the CNS plays a protective role in neuroinflammation.
人们越来越认识到肿瘤坏死因子（TNF）在多发性硬化症（MS）及其动物模型实验性自身免疫性脑脊髓炎（EAE）中发挥着多种保护和抗炎作用。最近，CXCL12已被确定为白细胞进入中枢神经系统（CNS）的关键抑制剂，也是入侵引发炎症的调节剂。在此，本文呈现了EAE大鼠中枢神经系统样本中TNF与CXCL12表达之间的正相关关系。此外，研究表明TNF可增强星形胶质细胞中CXCL12的表达。这些结果支持了一种观点，即中枢神经系统内产生的TNF在神经炎症中起保护作用。
