Naicker Nivashnee, Kharsany Ayesha B M, Werner Lise, van Loggerenberg Francois, Mlisana Koleka, Garrett Nigel, Abdool Karim Salim S
Centre for the AIDS Programme of Research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Private Bag X7, Congella, Durban, 4013, South Africa,
AIDS Behav. 2015 Jul;19(7):1305-16. doi: 10.1007/s10461-015-1002-5.
In South Africa young women bear a disproportionate burden of HIV infection however, risk factors for HIV acquisition are not fully understood in this setting. In a cohort of 245 women, we used proportional hazard regression analysis to examine the association of demographic, clinical and behavioural characteristics with HIV acquisition. The overall HIV incidence rate (IR) was 7.20 per 100 women years (wy), 95 % confidence interval (CI) 4.50-9.80. Women 18-24 years had the highest HIV incidence (IR 13.20 per 100 wy, 95 % CI 6.59-23.62) and were almost three times more likely to acquire HIV compared to women 25 years and older [adjusted Hazard Ratio (aHR) 2.61, 95 % CI 1.05-6.47]. Similarly, women in relationships with multiple sex partners had more than twice the risk of acquiring HIV when compared to women who had no partner or who had a husband or stable partner (aHR 2.47, 95 % CI 0.98-6.26). HIV prevention programmes must address young women's vulnerability and sex partner reduction in this setting.
在南非，年轻女性承受着不成比例的艾滋病毒感染负担，然而，在这种情况下，艾滋病毒感染的危险因素尚未完全明了。在一个由245名女性组成的队列中，我们使用比例风险回归分析来研究人口统计学、临床和行为特征与艾滋病毒感染之间的关联。艾滋病毒的总体发病率为每100名女性年7.20例，95%置信区间为4.50 - 9.80。18 - 24岁的女性艾滋病毒发病率最高（每100名女性年13.20例，95%置信区间为6.59 - 23.62），与25岁及以上的女性相比，感染艾滋病毒的可能性几乎高出两倍[调整后风险比(aHR)为2.61，95%置信区间为1.05 - 6.47]。同样，与没有伴侣或有丈夫或稳定伴侣的女性相比，有多个性伴侣的女性感染艾滋病毒的风险高出两倍多（aHR为2.47，95%置信区间为0.98 - 6.26）。在这种情况下，艾滋病毒预防计划必须解决年轻女性的脆弱性和减少性伴侣的问题。
