Naumenko E V, Maslova L N, Gordienko N I, Amstyslavski S Y, Dygalo N N, Markel A L
Institute of Cytology and Genetics, Siberian Department of the Academy of Sciences of the U.S.S.R., Novosibirsk.
Brain Res Dev Brain Res. 1989 Apr 1;46(2):205-12. doi: 10.1016/0165-3806(89)90284-8.
A long-lasting decrease of the basal and stress-induced arterial blood pressure was obtained in rats with inherited emotional stress-induced arterial hypertension by means of injections of the dopamine precursor L-DOPA during early development (21-25 days after birth). The restoring effect of L-DOPA was produced through enhancement of synthesis of the brain noradrenaline and, perhaps, adrenaline. The effect was associated with a normalization of the response of the brain adrenergic system to noradrenaline and, presumably, with increase of tyrosine hydroxylase activity in the cortex and hindbrain.
通过在发育早期（出生后21 - 25天）给遗传性情绪应激诱导的动脉高血压大鼠注射多巴胺前体L - 多巴，可使基础血压和应激诱导的动脉血压出现长期降低。L - 多巴的恢复作用是通过增强脑去甲肾上腺素或许还有肾上腺素的合成来实现的。该作用与脑肾上腺素能系统对去甲肾上腺素反应的正常化有关，并且推测与皮质和后脑酪氨酸羟化酶活性的增加有关。
