Naumenko E V, Maslova L N, Markel' A L, Gordienko N I
Biull Eksp Biol Med. 1987 Oct;104(10):464-6.
In a newly developed rat strain with inherited stress-sensitive arterial hypertension (ISSAH) an attempt was made to reduce arterial blood pressure by L-DOPA injections during a short time period of the early ontogenesis. It was shown that L-DOPA injections to rats on days 7-9 or 14-16 of life had no effect. The same procedure performed on 21-23 or 21-25-day-old rats was followed by a decrease in the basal and stress-induced arterial blood pressure levels, measured in adulthood. Injections of dopamine-beta-hydroxylase inhibitor (FLA-59) with parallel L-DOPA administration completely blocked the blood pressure decreasing effect. It can be suggested that injections of L-DOPA in the 4th week of post-natal life reduce the blood pressure level in ISSAH rats by enhancing the rate of brain noradrenaline biosynthesis.
在一种新培育的具有遗传性应激敏感性动脉高血压（ISSAH）的大鼠品系中，尝试在个体发育早期的短时间内通过注射左旋多巴来降低动脉血压。结果表明，在出生后第7 - 9天或14 - 16天给大鼠注射左旋多巴没有效果。而在21 - 23日龄或21 - 25日龄大鼠上进行相同操作后，成年期测量的基础血压和应激诱导的动脉血压水平均有所下降。同时注射多巴胺 - β - 羟化酶抑制剂（FLA - 59）与左旋多巴完全阻断了血压降低的效果。可以推测，出生后第4周注射左旋多巴可通过提高脑去甲肾上腺素的生物合成速率来降低ISSAH大鼠的血压水平。
