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金（I）催化炔丙胺与醛的环化反应：2,5 - 二甲基吡嗪的一锅法串联合成

Au(I)-catalyzed annulation of propargyl amine with aldehydes: one-pot cascade synthesis of 2,5-dimethylpyrazines.

作者信息

Su Ji, Liu Huixin, Hua Ruimao

机构信息

Department of Chemistry, Tsinghua University, Beijing 100084, China.

National Engineering Laboratory for Rice and Byproduct Deep Processing, Central South University of Forestry and Technology, Changsha 410004, China.

出版信息

Int J Mol Sci. 2015 Feb 5;16(2):3599-608. doi: 10.3390/ijms16023599.

DOI:10.3390/ijms16023599
PMID:25664863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4346915/
Abstract

3-Substituted 2,5-dimethylpyrazines were synthesized in high yields via a one-pot cascade annulation of easily available propargyl amine with aldehydes catalyzed by Au(PPh2Cy)Cl.

摘要

通过金（二苯基环戊基膦）氯催化易得的炔丙胺与醛的一锅串联环化反应，以高产率合成了3-取代的2,5-二甲基吡嗪。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0d/4346915/ac7570d1edb2/ijms-16-03599-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0d/4346915/cf6e9eee269a/ijms-16-03599-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0d/4346915/ac7570d1edb2/ijms-16-03599-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0d/4346915/cf6e9eee269a/ijms-16-03599-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0d/4346915/ac7570d1edb2/ijms-16-03599-g002.jpg

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