Hosseini-Sarvari Mona, Moeini Fatemeh
Department of Chemistry, Faculty of Science, Shiraz University, Shiraz 71454, I.R. Iran.
Comb Chem High Throughput Screen. 2014;17(5):439-49. doi: 10.2174/1386207316666131217104925.
In this paper, commercially available ZnO was found to be a highly effective catalyst for three-component coupling reactions of alkynes, aldehydes/or ketone and amines (A(3)-coupling) via C-H activation. The reactions could be applied to both aromatic and aliphatic aldehydes. Nearly quantitative yields of the desired products were obtained in most cases. No co-catalyst or activator is required, and water is the only by-product in the reactions. Heterogeneous nature of the catalyst made it reusable for further chemical reactions.
在本文中，发现市售的氧化锌是一种通过C-H活化实现炔烃、醛/酮和胺的三组分偶联反应（A(3)偶联）的高效催化剂。该反应可应用于芳香醛和脂肪醛。在大多数情况下，所需产物的产率接近定量。该反应无需助催化剂或活化剂，且水是唯一的副产物。催化剂的多相性质使其可重复用于进一步的化学反应。
