Jonasson A, Larsson B, Lecander I, Astedt B
Department of Obstetrics and Gynecology, University Hospital, Huddinge, Sweden.
Int J Gynaecol Obstet. 1989 May;29(1):73-7. doi: 10.1016/0020-7292(89)90132-x.
Increased blood loss (BL) has been reported after cervical dilatation by laminaria tent in legal abortions. The BL was measured in 72 women in whom first trimester legal vacuum aspiration was performed. The cervical canal was dilatated by laminaria tent in 37 patients, and mechanically with Hegar dilators in 35 patients. BL was studied in relation to the plasminogen activators (u-PA, t-PA) and the plasminogen activator inhibitors (PAI-1, PAI-2) in the decidua and placenta. There was no significant difference in BL between the two groups. Decidual PAI-1 concentrations were significantly higher in the laminaria tent group than in the Hegar dilator group. An inactivation of u-PA by PAI-1 might explain the lack of increase in BL among the laminaria tent group.
据报道，在合法堕胎中使用海藻棒扩张宫颈后会出现失血增加（BL）的情况。对72名进行孕早期合法真空吸引术的女性进行了失血量测量。37例患者使用海藻棒扩张宫颈管，35例患者使用海格扩张器进行机械扩张。研究了蜕膜和胎盘中的纤溶酶原激活剂（u-PA、t-PA）和纤溶酶原激活剂抑制剂（PAI-1、PAI-2）与失血量的关系。两组之间的失血量没有显著差异。海藻棒组的蜕膜PAI-1浓度显著高于海格扩张器组。PAI-1对u-PA的失活可能解释了海藻棒组失血量没有增加的原因。
