Zaydon C, Bogaars H A, Tucci J R
Division of Endocrinology and Metabolism, Roger Williams General Hospital, Brown University Program in Medicine, Providence 02908.
Int J Gynaecol Obstet. 1989 May;29(1):87-90. doi: 10.1016/0020-7292(89)90135-5.
Urinary and serum steroid measurements were obtained in a 48-year-old female before and after the removal of a virilizing granulosa cell tumor (GCT). Preoperatively, serum testosterone was markedly elevated while 17-ketosteroid (17-KS) and estrogen excretion were normal. Chorionic gonadotropin administration effected a marked rise in urinary 17-KS excretion and serum testosterone while oral contraceptive therapy for 21 days decreased serum testosterone to normal. With tumor resection, serum testosterone fell to normal and subsequent administration of HCG had no stimulatory effect on serum testosterone or urinary 17-KS excretion. The patient's clinical response and 8-year followup attest to the tumor's unusual virilizing role.
对一名48岁女性在切除具有男性化作用的颗粒细胞瘤（GCT）前后进行了尿液和血清类固醇检测。术前，血清睾酮显著升高，而17-酮类固醇（17-KS）和雌激素排泄正常。给予绒毛膜促性腺激素后，尿17-KS排泄和血清睾酮显著升高，而口服避孕药21天则使血清睾酮降至正常。肿瘤切除后，血清睾酮降至正常，随后给予人绒毛膜促性腺激素对血清睾酮或尿17-KS排泄无刺激作用。患者的临床反应和8年随访证明了该肿瘤不同寻常的男性化作用。
