Balta Sevket, Celik Turgay, Mikhailidis Dimitri P, Ozturk Cengiz, Demirkol Sait, Aparci Mustafa, Iyisoy Atila
Department of Cardiology, Eskisehir Military Hospital, Eskişehir, Turkey
Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
Clin Appl Thromb Hemost. 2016 Jul;22(5):405-11. doi: 10.1177/1076029615569568. Epub 2015 Feb 9.
Inflammation plays an important role in the pathophysiology of vascular disease. In this review, we consider the associations between the neutrophil-lymphocyte ratio (NLR; an indicator of inflammation) and vascular disease and its associated risk factors. The NLR has received attention due to its role as an independent prognostic factor for coronary artery disease. The NLR can also be affected by atherosclerotic risk factors, such as hypercholesterolemia, metabolic syndrome, diabetes, and hypertension. Importantly, it can predict mortality in cardiovascular diseases. There are also reports of a positive correlation between the NLR and commonly used inflammatory markers. Inflammation is important not only in pathophysiology but also clinical outcomes of many diseases. The NLR is a widely available, easily derived, and reproducible marker of inflammation. Unlike many other inflammatory markers, the NLR is inexpensive and readily available and it provides additional risk stratification beyond conventional risk scores.
炎症在血管疾病的病理生理学中起着重要作用。在本综述中，我们探讨中性粒细胞与淋巴细胞比值（NLR，一种炎症指标）与血管疾病及其相关危险因素之间的关联。NLR作为冠状动脉疾病的独立预后因素，已受到关注。NLR也会受到动脉粥样硬化危险因素的影响，如高胆固醇血症、代谢综合征、糖尿病和高血压。重要的是，它可以预测心血管疾病的死亡率。也有报道称NLR与常用的炎症标志物之间存在正相关。炎症不仅在病理生理学中很重要，在许多疾病的临床结局中也很重要。NLR是一种广泛可用、易于获取且可重复的炎症标志物。与许多其他炎症标志物不同，NLR价格低廉且易于获得，并且它能在传统风险评分之外提供额外的风险分层。
