哮喘和鼻炎所涉及的免疫球蛋白E反应与11号染色体q区之间的连锁关系。
Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q.
作者信息
Cookson W O, Sharp P A, Faux J A, Hopkin J M
机构信息
Osler Chest Unit, Churchill Hospital, Oxford.
出版信息
Lancet. 1989 Jun 10;1(8650):1292-5. doi: 10.1016/s0140-6736(89)92687-1.
PMID:2566826
Abstract
Family studies of IgE responses to common inhaled antigens have suggested dominant inheritance of atopy. Molecular genetic linkage analysis was used to confirm this proposal. In seven families the transmission of atopy was linked, with a maximum lod score of 5.58, to a DNA polymorphism defined by p lambda MS.51, which confirms dominant inheritance and assigns the gene locus to chromosome 11.
摘要
针对常见吸入性抗原的IgE反应的家族研究表明特应性呈显性遗传。采用分子遗传连锁分析来证实这一推测。在7个家族中，特应性的传递与由p lambda MS.51定义的DNA多态性相关联，最大对数优势得分为5.58，这证实了显性遗传并将该基因座定位于11号染色体。
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