Zhang Cheng, Li Shengbing, Zhang Xianxiang, Liu Hua, Luo Yong
Department of Endocrinology, Chongqing Three Gorges Central Hospital, Chongqing 400000, China.
Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, 400010 Chongqing, China.
Ann Endocrinol (Paris). 2015 Oct;76(5):601-13. doi: 10.1016/j.ando.2014.12.001. Epub 2015 Feb 7.
Studies based on Chinese populations reported that inconsistent results were found on the association of ApoE gene polymorphisms with type 2 diabetic nephropathy (T2DN). Therefore, we performed this meta-analysis to provide a reliable evaluation of the associations between ApoE gene polymorphisms and T2DN. MEDLINE, EMBASE, Chinese Wanfang database and Chinese VIP database were searched for studies that reported the associations of ApoE gene polymorphisms with type 2 diabetic nephropathy in a Chinese population up to Dec 2013. A meta-analysis was performed to assess heterogeneity and combine results by using software RevMan 4.3.1. Sensitivity analysis and publication bias were conducted. Data from 16 published studies involving 4320 individuals were eligible for inclusion. After heterogeneity test in each analysis, corresponding effect models were applied to quantitatively syntheses data. The ApoE allele e2 and genotype e2/e3 occurred more frequently in T2DN than in T2DNN and NC group. Their ORs and 95%CIs in T2DN were 1.75 (1.27-2.42) and 1.68 (1.20-2.38) when compared with T2DNN, respectively (P<0.05); 2.59 (1.74-3.85) and 2.43 (1.61-3.65) when compared with NC, respectively (P<0.05). The publication bias diagnostics test and sensitivity analysis confirmed the reliability and stability of this meta-analysis. These findings support the significant association between ApoE gene polymorphisms and T2DN. It was revealed that allele e2 and genotype e2/e3 were risk factors for T2DN and allele e3 and genotype e3/e3 played a protective role in T2DN. Further studies will be needed to confirm the conclusion.
基于中国人群的研究报告称，载脂蛋白E（ApoE）基因多态性与2型糖尿病肾病（T2DN）的关联结果并不一致。因此，我们进行了这项荟萃分析，以对ApoE基因多态性与T2DN之间的关联提供可靠评估。检索了MEDLINE、EMBASE、中国万方数据库和中国维普数据库，查找截至2013年12月报道中国人群中ApoE基因多态性与2型糖尿病肾病关联的研究。使用RevMan 4.3.1软件进行荟萃分析以评估异质性并合并结果。进行了敏感性分析和发表偏倚分析。来自16项已发表研究、涉及4320名个体的数据符合纳入标准。在每项分析中进行异质性检验后，应用相应的效应模型对数据进行定量综合分析。ApoE等位基因e2和基因型e2/e3在T2DN组中的出现频率高于T2DN非肾病组和正常对照组。与T2DN非肾病组相比，它们在T2DN组中的比值比（OR）及95%可信区间（CI）分别为1.75（1.27 - 2.42）和1.68（1.20 - 2.38）（P<0.05）；与正常对照组相比，分别为2.59（1.74 - 3.85）和2.43（1.61 - 3.65）（P<0.05）。发表偏倚诊断检验和敏感性分析证实了这项荟萃分析的可靠性和稳定性。这些发现支持ApoE基因多态性与T2DN之间存在显著关联。结果显示，等位基因e2和基因型e2/e3是T2DN的危险因素，而等位基因e3和基因型e3/e3在T2DN中起保护作用。需要进一步研究来证实这一结论。
