Henderson J T, Piquette-Miller M
Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada.
Clin Pharmacol Ther. 2015 Apr;97(4):308-13. doi: 10.1002/cpt.77. Epub 2015 Feb 24.
The blood-brain barrier (BBB) serves as a highly selective barrier separating the central nervous system from the systemic circulation. Although contributing to neurological health, the BBB restricts the ability of drugs to reach their site of action and thus presents a major challenge to the treatment of neurological disorders. Advances in our understanding of the complexity of the BBB have fostered development of novel pharmacometric models and drug delivery strategies to better predict and improve therapeutic access.
血脑屏障（BBB）是一种高度选择性的屏障，将中枢神经系统与体循环分隔开来。尽管血脑屏障有助于神经健康，但它限制了药物到达其作用部位的能力，因此对神经系统疾病的治疗构成了重大挑战。我们对血脑屏障复杂性认识的进展推动了新型药代动力学模型和药物递送策略的发展，以更好地预测和改善治疗药物的可达性。
