阿片类药物治疗慢性非癌痛：仍没有证据表明缓释阿片类药物具有优势。

Opioids for chronic noncancer pain: still no evidence for superiority of sustained-release opioids.

机构信息

National Competence Centre for Complex Symptom Disorders, Trondheim, Norway; Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Internal Medicine, Sørlandet Hospital Kristiansand, Kristiansand, Norway.

出版信息

Clin Pharmacol Ther. 2015 Feb;97(2):114-5. doi: 10.1002/cpt.26. Epub 2014 Dec 15.

DOI:10.1002/cpt.26

PMID:25670511

Abstract

Opioids are controversial in the treatment of chronic pain due to the risk of addiction, misuse, and death. Long-acting formulations of opioids have been hypothesized to improve pain relief, sleep quality, and lower the risk of side effects and addiction compared to short-acting formulations of opioids. Thus, several guidelines have recommended the use of long-acting opioid formulations over short-acting ones in the treatment of chronic noncancer pain. However, is there really evidence of their superiority?

摘要

阿片类药物在治疗慢性疼痛方面存在争议，因为存在成瘾、滥用和死亡的风险。长效阿片类药物制剂被假设可以改善疼痛缓解、睡眠质量，并降低与短期阿片类药物制剂相比的副作用和成瘾风险。因此，一些指南建议在治疗慢性非癌性疼痛时使用长效阿片类药物制剂而非短期制剂。然而，它们真的有优势的证据吗？