University of Kentucky, Anesthesiology , 800 Rose St, Lexington, 40536 , USA
Expert Opin Drug Deliv. 2014 Feb;11(2):155-8. doi: 10.1517/17425247.2014.866090. Epub 2013 Dec 4.
Chronic pain is frequently treated with our most potent analgesics, the opioids. While immediate-release opioids given every 3 - 4 h provide adequate analgesia for most patients with cancer pain and some patients with chronic nonmalignant pain, extended-release (ER) opioid formulations have been developed in the hope that patients with chronic pain would have improved analgesia, reduced side effects, more convenience, improved compliance, improved sleep and reduced nighttime pain. A more recent goal of the ER opioid product is to reduce prescription opioid addiction risk. This editorial will review the evidence that modern ER opioid formulations have advanced toward these goals.
慢性疼痛常采用我们最有效的镇痛药，即阿片类药物来治疗。虽然对于大多数癌痛患者和部分慢性非恶性疼痛患者，每 3-4 小时给予一次即释型阿片类药物即可提供充分的镇痛，但仍开发了控释（ER）阿片类药物剂型，以期慢性疼痛患者的镇痛效果得以改善、副作用减少、更方便、顺应性提高、睡眠改善和夜间疼痛减轻。ER 阿片类药物产品的近期目标是降低处方阿片类药物成瘾风险。本社论将回顾现代 ER 阿片类药物制剂在朝着这些目标前进的证据。
