Institut Pasteur, Unité des Interactions Bactéries-Cellules, 75015 Paris, France; Institut National de la Santé et de la Recherche Médicale (Inserm) Unité 604, 75015 Paris, France; Institut National de la Recherche Agronomique (INRA), Unité USC2020, 75015 Paris, France.
Institut Pasteur, Unité des Interactions Bactéries-Cellules, 75015 Paris, France; Institut National de la Santé et de la Recherche Médicale (Inserm) Unité 604, 75015 Paris, France; Institut National de la Recherche Agronomique (INRA), Unité USC2020, 75015 Paris, France.
Trends Cell Biol. 2015 Jun;25(6):330-8. doi: 10.1016/j.tcb.2015.01.003. Epub 2015 Feb 7.
Listeria monocytogenes, a facultative intracellular bacterium responsible for severe foodborne infections, is now recognized as a multifaceted model in infection biology. Comprehensive studies of the molecular and cellular basis of the infection have unraveled how the bacterium crosses the intestinal and feto-placental barriers, invades several cell types in which it multiplies and moves, and spreads from cell to cell. Interestingly, although Listeria does not actively invade host cell organelles, it can interfere with their function. We discuss the effect of Listeria on the endoplasmic reticulum (ER) and the mechanisms leading to the fragmentation of the mitochondrial network and its consequences, and review the strategies used by Listeria to subvert nuclear functions, more precisely to control host gene expression at the chromatin level.
李斯特菌（Listeria monocytogenes）是一种兼性细胞内细菌，可引起严重的食源性感染，目前被认为是感染生物学中一种多面的模式生物。对感染的分子和细胞基础的综合研究揭示了细菌如何穿过肠道和胎盘中的屏障，入侵并在其中增殖和转移的几种细胞类型，以及从一个细胞传播到另一个细胞。有趣的是，尽管李斯特菌不会主动入侵宿主细胞细胞器，但它可以干扰其功能。我们讨论了李斯特菌对内质网（ER）的影响以及导致线粒体网络碎片化的机制及其后果，并回顾了李斯特菌用于颠覆核功能的策略，更确切地说，是用于在染色质水平上控制宿主基因表达。
