Department of Psychiatry, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Psychiatry, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Republic of Korea. ; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Psychiatry Investig. 2015 Jan;12(1):1-8. doi: 10.4306/pi.2015.12.1.1. Epub 2015 Jan 12.
Remarkable progresses have been achieved regarding the understanding of the neurobiological bases of pain and depression. The principal role of neurotransmitters, neuromodulators, and neurohormones has been proposed in the development of pain and depression. With the progression of molecular biology, an intricate interaction among biological factors accountable to the development and management of pain and depression has been also shown in a numerous preclinical and clinical researches. This mini-review will briefly describe the current issues and future research direction for better understanding of the relationship between pain and depression.
在理解疼痛和抑郁的神经生物学基础方面已经取得了显著进展。神经递质、神经调质和神经激素在疼痛和抑郁的发展中起着主要作用。随着分子生物学的发展，大量的临床前和临床研究表明，生物因素在疼痛和抑郁的发展和管理中存在着复杂的相互作用。这篇简要综述将简要描述当前的问题和未来的研究方向，以更好地理解疼痛和抑郁之间的关系。
