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碳水化合物策略用于（-）-aspergillide C 的全合成。

A carbohydrate approach for the formal total synthesis of (-)-aspergillide C.

机构信息

Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.

Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India ; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Hyderabad, 500037, India ; Medicinal Chemistry & Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.

出版信息

Beilstein J Org Chem. 2014 Dec 23;10:3122-6. doi: 10.3762/bjoc.10.329. eCollection 2014.

DOI:10.3762/bjoc.10.329
PMID:25670981
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4311580/
Abstract

An enantioselective formal total synthesis of aspergillide C is accomplished using commercially available tri-O-acetyl-D-galactal employing a Ferrier-type C-glycosylation, utilizing a Trost hydrosilylation and protodesilylation as key reactions.

摘要

采用 Ferrier 型 C-糖苷化反应，利用 Trost 硅氢化反应和脱硅氢化反应作为关键反应，使用商业可得的三-O-乙酰基-D-半乳糖醛酸实现了 Aspergillide C 的对映选择性形式全合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a578/4311580/012aa2e7b609/Beilstein_J_Org_Chem-10-3122-g002.jpg

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