曲霉菌素D的立体选择性全合成
Stereoselective total synthesis of Aspergillide D.
作者信息
Kumari Krishnaiah, Syed Tasqeeruddin, Krishna A M S, Muvvala Subhashini, Nowduri Annapurna, Sridhar Chidara, Saxena Abhishek
机构信息
GVK Biosciences Private Limited, Hyderabad, India.
Department of Engineering Chemistry, Andhra University, Visakhapatnam, India.
出版信息
Nat Prod Res. 2023 Oct-Nov;37(20):3402-3408. doi: 10.1080/14786419.2022.2078321. Epub 2022 Jun 6.
The total synthesis of the 16-membered Polyhydroxylated macrolide, Aspergillide D has been accomplished utilizing the Grignard reaction, Sharpless asymmetric epoxidation Regioselective ring opening of epoxy alcohol, Wittig olefination and Yamaguchi macrolactonisation as key steps. 3-butene-1-ol has been utilized as the starting material.
利用格氏反应、夏普莱斯不对称环氧化、环氧醇的区域选择性开环、维蒂希烯烃化反应和山口大环内酯化反应作为关键步骤，完成了16元多羟基大环内酯类化合物曲霉内酯D的全合成。以3-丁烯-1-醇作为起始原料。
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