使用非去极化神经肌肉阻滞剂时神经肌肉阻滞开始期间的四个成串刺激衰减

Train-of-four fade during onset of neuromuscular block with nondepolarising neuromuscular blocking agents.

作者信息

Gibson F M, Mirakhur R K

机构信息

Department of Clinical Anaesthesia, Royal Victoria Hospital, Belfast, N. Ireland, UK.

出版信息

Acta Anaesthesiol Scand. 1989 Apr;33(3):204-6. doi: 10.1111/j.1399-6576.1989.tb02890.x.

DOI:10.1111/j.1399-6576.1989.tb02890.x

PMID:2567104

Abstract

Fade in the train-of-four (TOF) responses during onset of neuromuscular block was studied following administration of atracurium (225 or 450 micrograms/kg), vecuronium (40 or 80 micrograms/kg), pancuronium (60 or 120 micrograms/kg) and tubocurarine (450 micrograms/kg). TOF ratios were measured at approximate heights of T1 (first response in the TOF) of 75, 50 and 25%. Fade in TOF increased as the height of T1 decreased, with maximum fade being observed at T1 of 25%. The greatest difference between relaxants was observed at T1 of 25%, vecuronium showing the least fade and pancuronium, atracurium and tubocurarine showing increasing fade, in that order. The difference between atracurium and tubocurarine or between vecuronium and pancuronium was not significant, but the degree of TOF fade was significantly greater with atracurium and tubocurarine in comparison to vecuronium or pancuronium.

摘要

在给予阿曲库铵（225或450微克/千克）、维库溴铵（40或80微克/千克）、泮库溴铵（60或120微克/千克）和筒箭毒碱（450微克/千克）后，研究了神经肌肉阻滞开始时四个成串刺激（TOF）反应的衰减情况。在T1（TOF中的第一个反应）近似高度为75%、50%和25%时测量TOF比值。随着T1高度降低，TOF衰减增加，在T1为25%时观察到最大衰减。在T1为25%时观察到不同肌松药之间的最大差异，维库溴铵衰减最少，泮库溴铵、阿曲库铵和筒箭毒碱衰减依次增加。阿曲库铵和筒箭毒碱之间或维库溴铵和泮库溴铵之间的差异不显著，但与维库溴铵或泮库溴铵相比，阿曲库铵和筒箭毒碱的TOF衰减程度显著更大。