Shiraishi H, Suzuki H, Suzuki T, Katsumata N, Ogawa S
Department of Anaesthesiology, Surugadai Nihon University Hospital, Tokyo, Japan.
Can J Anaesth. 1992 Dec;39(10):1099-104. doi: 10.1007/BF03008381.
This study was performed to evaluate the inhibitory effect on motor nerve terminals by rocuronium using recovery curves of muscle compound action potentials (CAPs) and train-of-four ratios (TOFRs) in anaesthetized cats, and to compare the results with other relaxants reported previously. Recovery curves were derived from the amplitude of the CAP induced in the gastrocnemius muscle by the second of a paired stimulus (test response) to the sciatic nerve and compared with results evoked by the first component (conditioning response). The interval between the paired stimuli was increased stepwise from 7 to 1,000 msec, and the differences in amplitude of the test and conditioning responses were plotted on a graph by relating the changes in paired intervals. The recovery curve after rocuronium was less inhibited than after pancuronium, (100.4 +/- 5.9%, 82.3 +/- 6.7% and 68.5 +/- 6.7% at 60, 100 and 500 msec intervals, compared with 70.3 +/- 3.3%, 59.0 +/- 4.7% and 46.7 +/- 4.3% after pancuronium (P < 0.05). The recovery curves with d-tubocurarine were more depressed than with pancuronium; however, the RC with vecuronium was similar to that of rocuronium. The degree of fade in TOF by rocuronium was also less than those seen with d-tubocurarine and pancuronium. The results obtained suggest that rocuronium has less inhibitory effect on motor nerve terminals than do d-tubocurarine and pancuronium, and has a similar effect to that of vecuronium.
本研究旨在通过在麻醉猫中使用肌肉复合动作电位（CAPs）恢复曲线和四个成串刺激比率（TOFRs）来评估罗库溴铵对运动神经末梢的抑制作用，并将结果与先前报道的其他松弛剂进行比较。恢复曲线来自于对坐骨神经的成对刺激中的第二个刺激（测试反应）在腓肠肌中诱发的CAP幅度，并与第一个成分（条件反应）诱发的结果进行比较。成对刺激之间的间隔从7毫秒逐步增加到1000毫秒，通过关联成对间隔的变化，将测试反应和条件反应的幅度差异绘制在图表上。罗库溴铵后的恢复曲线比泮库溴铵后的恢复曲线受抑制程度小（在60、100和500毫秒间隔时分别为100.4±5.9%、82.3±6.7%和68.5±6.7%，而泮库溴铵后分别为70.3±3.3%、59.0±4.7%和46.7±4.3%，P<0.05）。d-筒箭毒碱的恢复曲线比泮库溴铵的更受抑制；然而，维库溴铵的恢复曲线与罗库溴铵的相似。罗库溴铵引起的四个成串刺激（TOF）衰减程度也小于d-筒箭毒碱和泮库溴铵。所得结果表明，罗库溴铵对运动神经末梢的抑制作用小于d-筒箭毒碱和泮库溴铵，且与维库溴铵的作用相似。
