Storella R J, Slomowitz S A, Rosenberg H
Department of Anesthesiology, Hahnemann University, Philadelphia, PA 19102.
Can J Anaesth. 1991 Apr;38(3):401-7. doi: 10.1007/BF03007631.
The relationships between the block-of-twitch and train-of-four fade in the presence of nondepolarizing neuromuscular blocking drugs (d-tubocurarine, vecuronium and pancuronium) were examined in vitro by measuring the contractile tension from mouse phrenic nerve-diaphragm preparations. The slope of the block/fade relationship differed between onset of and recovery from neuromuscular block following single doses of d-tubocurarine, vecuronium or pancuronium. Decreasing the dose of d-tubocurarine or using a divided dose technique to accelerate onset (i.e., priming) increased the amount of fade for a given amount of block. In addition, the block/fade relationships for cumulative dosing and sequential dilution were the same when measurements were made at steady-state for several doses. It is concluded that the block/fade relationship in the mouse phrenic nerve-diaphragm preparation is variable, and is related to the time course of the neuromuscular block. In addition, the block/fade relationships for d-tubocurarine, vecuronium and pancuronium did not differ when determined at steady-state.
通过测量小鼠膈神经 - 膈肌标本的收缩张力，在体外研究了非去极化神经肌肉阻滞药物（右旋筒箭毒碱、维库溴铵和泮库溴铵）存在时单次颤搐阻滞与四个成串刺激衰减之间的关系。单次给予右旋筒箭毒碱、维库溴铵或泮库溴铵后，神经肌肉阻滞开始时和恢复时的阻滞/衰减关系斜率有所不同。减少右旋筒箭毒碱的剂量或采用分次给药技术加速起效（即预注），对于给定程度的阻滞，会增加衰减量。此外，当对多个剂量进行稳态测量时，累积给药和序贯稀释的阻滞/衰减关系相同。得出结论，小鼠膈神经 - 膈肌标本中的阻滞/衰减关系是可变的，并且与神经肌肉阻滞的时间进程有关。此外，在稳态下测定时，右旋筒箭毒碱、维库溴铵和泮库溴铵的阻滞/衰减关系没有差异。
