朱顶红属植物对人乳腺癌细胞转移的抑制作用。
Inhibitory effect of Erythronium japonicum on the human breast cancer cell metastasis.
机构信息
Department of Food & Nutrition / Research Institute of Human Ecology, Mokpo National University, 1666, Yeongsan-ro, Cheonggye-myeon, Muan-gun, Jeonnam 534-729, Korea.
Nature Pure Korea Inc. Jeonnam 517-803, Korea.
出版信息
Nutr Res Pract. 2015 Feb;9(1):17-21. doi: 10.4162/nrp.2015.9.1.17. Epub 2015 Jan 28.
BACKGROUND/OBJECTIVES: In this study, the inhibitory effect of Erythronium japonicum extracts on the metastasis of MDA-MB-231 human breast cancer cell line was determined.
MATERIALS/METHODS: Cells were cultured with DMSO or with 50, 75, 100 or 250 µg/ml of Erythronium japonicum methanol or ethanol extract.
RESULTS
Both methanol and ethanol extracts significantly inhibited the growth and induced apoptosis of MDA-MB-231 cells in a dose-dependent manner. Erythronium japonicum extracts inhibited the adhesion of MDA-MB-231 cells. The invasion of breast cancer cells was suppressed by Erythronium japonicum extracts in a dose-dependent manner. The motility and MMP-2 and MMP-9 activities were also inhibited by both methanol and ethanol extracts.
CONCLUSIONS
Our results collectively indicate that Erythronium japonicum extracts inhibit the growth, adhesion, migration and invasion as well as induce the apoptosis of human breast cancer cells. Clinical application of Erythronium japonicum as a potent chemopreventive agent may be helpful in limiting breast cancer invasion and metastasis.
背景/目的：在这项研究中，测定了獐牙菜提取物对 MDA-MB-231 人乳腺癌细胞系转移的抑制作用。
材料/方法：用 DMSO 或 50、75、100 或 250μg/ml 的獐牙菜甲醇或乙醇提取物培养细胞。
结果
甲醇和乙醇提取物均显著地以剂量依赖的方式抑制 MDA-MB-231 细胞的生长并诱导其凋亡。獐牙菜提取物抑制 MDA-MB-231 细胞的黏附。獐牙菜提取物以剂量依赖的方式抑制乳腺癌细胞的侵袭。细胞的迁移和 MMP-2 和 MMP-9 活性也被甲醇和乙醇提取物所抑制。
结论
我们的结果表明獐牙菜提取物抑制人乳腺癌细胞的生长、黏附、迁移和侵袭，并诱导其凋亡。獐牙菜作为一种有效的化学预防剂的临床应用可能有助于限制乳腺癌的侵袭和转移。
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