Coakley J C, Francis I, Gold H, Mathur K, Connelly J F
Department of Clinical Biochemistry, Royal Children's Hospital, Parkville, Victoria, Australia.
Aust Paediatr J. 1989 Feb;25(1):25-30. doi: 10.1111/j.1440-1754.1989.tb01408.x.
Between May 1977 and December 1986, the Victorian Thyroid Screening Programme tested approximately 570,000 newborns for congenital hypothyroidism. One hundred and sixty-six cases of primary hypothyroidism, confirmed by formal thyroid function tests, were identified, of which 24 were later found to be transient. In addition, there were two patients with permanent dyshormonogenesis who passed through a stage of being biochemically euthyroid and so could have been diagnosed mistakenly as transient hypothyroidism. Fourteen of the transient cases were due to excessive intake of iodine. In two, this was due to maternal ingestion of iodide during pregnancy and in 12 the babies received large amounts of topical iodine antiseptic. Two cases were caused by maternal anti-thyroid antibodies and in eight instances the cause was unknown. The large number of cases due to the topical application of iodine antiseptic emphasizes the need for caution when using this substance in neonates.
1977年5月至1986年12月期间，维多利亚甲状腺筛查项目对约570,000名新生儿进行了先天性甲状腺功能减退症检测。经正规甲状腺功能测试确诊了166例原发性甲状腺功能减退症病例，其中24例后来被发现是暂时性的。此外，有两名永久性激素合成障碍患者曾经历过甲状腺功能生化指标正常的阶段，因此可能被误诊为暂时性甲状腺功能减退症。14例暂时性病例是由于碘摄入过量。其中2例是由于母亲在孕期摄入碘化物，12例是因为婴儿接受了大量局部碘消毒剂。2例由母亲的抗甲状腺抗体引起，8例病因不明。大量病例是由于局部应用碘消毒剂所致，这凸显了在新生儿中使用该物质时需谨慎的必要性。
