Cheng Yuan-Lung, Wang Yuan-Chen, Lan Keng-Hsin, Huo Teh-Ia, Huang Yi-Hsiang, Su Chien-Wei, Lin Han-Chieh, Lee Fa-Yauh, Wu Jaw-Ching, Lee Shou-Dong
Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.
Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Ann Hepatol. 2015 Mar-Apr;14(2):181-9.
Although many studies have tried to clarify the association between hepatitis C virus (HCV) infection and metabolic syndrome, few studies have comprehensively assessed their relationship stratified by different demographic characteristics. We aimed to investigate the correlation between metabolic syndrome and anti-HCV seropositivity in Taiwan. This study enrolled consecutive subjects who had received health check-up services at Taipei Veterans General Hospital from 2002 to 2009. Metabolic syndrome was diagnosed according to the criteria defined by the International Diabetes Federation Task Force on Epidemiology and Prevention. Among the 30616 subjects enrolled in this study, the prevalence of positive anti-HCV serology was 2.7%, and 28.8% were diagnosed with metabolic syndrome. By multivariate analysis, metabolic syndrome was associated with higher body mass index, older age, male sex, a higher level of alanine aminotransferase, gamma-glutamyltransferase, platelet count and the presence of fatty liver whereas anti-HCV seropositivity was not an independent variable for metabolic syndrome. Further stratifying the subjects by age and sex, and there was still no significant difference in HCV status between those with and without metabolic syndrome. Moreover, the stage of liver fibrosis represented by aspartate aminotransferase to platelet ratio index was also not correlated with metabolic syndrome in the subjects with anti-HCV seropositivity. In conclusion, although subjects with anti-HCV seropositivity had higher fasting glucose levels and lower cholesterol and triglyceride levels compared to those with negative anti-HCV test, anti-HCV seropositivity was not associated with metabolic syndrome based on the current diagnostic criteria irrespective of age, gender and the stage of hepatic fibrosis.
尽管许多研究试图阐明丙型肝炎病毒（HCV）感染与代谢综合征之间的关联，但很少有研究按不同人口统计学特征对二者关系进行全面评估。我们旨在调查台湾地区代谢综合征与抗-HCV血清学阳性之间的相关性。本研究纳入了2002年至2009年在台北荣民总医院接受健康检查服务的连续受试者。代谢综合征根据国际糖尿病联盟流行病学与预防特别工作组定义的标准进行诊断。在本研究纳入的30616名受试者中，抗-HCV血清学阳性率为2.7%，28.8%被诊断为代谢综合征。多因素分析显示，代谢综合征与较高的体重指数、年龄较大、男性、较高水平的丙氨酸转氨酶、γ-谷氨酰转移酶、血小板计数以及脂肪肝的存在相关，而抗-HCV血清学阳性并非代谢综合征的独立变量。进一步按年龄和性别对受试者进行分层，有或无代谢综合征者的HCV状态仍无显著差异。此外，在抗-HCV血清学阳性的受试者中，以天冬氨酸转氨酶与血小板比值指数表示的肝纤维化阶段也与代谢综合征无关。总之，尽管与抗-HCV检测阴性者相比，抗-HCV血清学阳性者空腹血糖水平较高，胆固醇和甘油三酯水平较低，但根据目前的诊断标准，无论年龄、性别和肝纤维化阶段如何，抗-HCV血清学阳性与代谢综合征均无关联。
