印度楝对胃黏膜损伤的胃黏膜保护作用：肠嗜铬细胞和5-羟色胺的作用
Gastric mucosal protection by aegle marmelos against gastric mucosal damage: role of enterochromaffin cell and serotonin.
作者信息
Singh Purnima, Dutta Shubha R, Guha Debjani
机构信息
Department of Physiology, Vyas Dental College and Hospital, Jodhpur, Rajasthan, India.
出版信息
Saudi J Gastroenterol. 2015 Jan-Feb;21(1):35-42. doi: 10.4103/1319-3767.151224.
BACKGROUND/AIMS: Serotonin (5-hydroxytryptamine; 5-HT) released from enterochromaffin (EC) cells in gastric mucosa inhibits gastric acidity by increasing the gastric mucus secretion. In the present study, we evaluated the effect of aqueous extract of Aegle marmelos (AM) ripe fruit pulp (250 mg/kg body weight) on mean ulcer index (MUI), EC cells, 5-HT content, and adherent mucosal thickness of ulcerated gastric tissue in adult albino rats.
MATERIAL AND METHODS
Ulceration was induced by using aspirin (500 mg/kg, p.o.), cerebellar nodular lesion and applying cold-restraint stress.
RESULTS
In all cases increased MUI in gastric tissue along with decreased EC cell count was observed with concomitant decrease of 5-HT content and adherent mucosal thickness (P < 0.05). Pretreatment with AM for 14 days decreased MUI, increased EC cell count, and 5-HT content as well as adherent mucosal thickness in all ulcerated group (P < 0.05).
CONCLUSION
AM produces gastric mucosal protection mediated by increased EC cell count and 5-HT levels.
背景/目的：胃黏膜肠嗜铬（EC）细胞释放的5-羟色胺（5-HT）通过增加胃黏液分泌来抑制胃酸分泌。在本研究中，我们评估了成年白化病大鼠中印度枳椇（AM）成熟果实果肉水提取物（250mg/kg体重）对平均溃疡指数（MUI）、EC细胞、5-HT含量以及溃疡胃组织黏附黏膜厚度的影响。
材料与方法
通过给予阿司匹林（500mg/kg，口服）、小脑结节损伤以及施加冷束缚应激诱导溃疡形成。
结果
在所有病例中，均观察到胃组织中MUI增加，同时EC细胞计数减少，5-HT含量和黏附黏膜厚度也随之降低（P<0.05）。在所有溃疡组中，用AM预处理14天可降低MUI，增加EC细胞计数、5-HT含量以及黏黏附黏膜厚度（P<0.05）。
结论
AM通过增加EC细胞计数和5-HT水平介导胃黏膜保护作用。
Zotero 插件